MXI1 Human shRNA Plasmid Kit (Locus ID 4601)
CAT#: TF311331
MXI1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
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Specifications
Product Data | |
Product Name | MXI1 Human shRNA Plasmid Kit (Locus ID 4601) |
Locus ID | 4601 |
UniProt ID | P50539 |
Synonyms | bHLHc11; MAD2; MXD2; MXI |
Vector | pRFP-C-RS |
Format | Retroviral plasmids |
Kit Components | MXI1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 4601). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
RefSeq | NM_001008541, NM_005962, NM_130439, NM_001008541.1, NM_130439.1, NM_130439.2, NM_130439.3, NM_005962.1, NM_005962.2, NM_005962.3, NM_005962.4, BC012907, BC012907.1, BC035128, BC035128.1, BC016678, BM668806, BM927870, NM_005962.5 |
Summary | Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
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