Nrf2 (NFE2L2) Human shRNA Plasmid Kit (Locus ID 4780)
CAT#: TG311194
NFE2L2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
Cited in 7 publications. |
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经常一起买 (2)
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Specifications
Product Data | |
Product Name | Nrf2 (NFE2L2) Human shRNA Plasmid Kit (Locus ID 4780) |
Locus ID | 4780 |
UniProt ID | Q16236 |
Synonyms | HEBP1; IMDDHH; Nrf-2; NRF2 |
Vector | pGFP-V-RS |
Format | Retroviral plasmids |
Kit Components | NFE2L2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 4780). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
RefSeq | NM_001145412, NM_001145413, NM_001313900, NM_001313901, NM_001313902, NM_001313903, NM_001313904, NM_006164, NM_006164.1, NM_006164.2, NM_006164.3, NM_006164.4, NM_001145412.1, NM_001145412.2, NM_001145412.3, NM_001145413.1, NM_001145413.2, NM_001145413.3, BC011558, BC011558.1, NM_006164.5 |
Summary | This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (7)
The use of this RNAi has been cited in the following citations: |
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Targeting the NRF2/HO-1 Antioxidant Pathway in FLT3-ITD-Positive AML Enhances Therapy Efficacy
,null,
Antioxidants
,PubMed ID 35453402
[NFE2L2]
|
Effect of the Nrf2-ARE signaling pathway on biological characteristics and sensitivity to sunitinib in renal cell carcinoma
,Ji, S;Xiong, Y;Zhao, X;Liu, Y;Yu, LQ;,
Oncol Lett
,PubMed ID 31186733
[NFE2L2]
|
Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane
,Wang, Y;Mandal, AK;Son, YO;Pratheeshkumar, P;Wise, JTF;Wang, L;Zhang, Z;Shi, X;Chen, Z;,
Toxicol. Appl. Pharmacol.
,PubMed ID 29885333
[NFE2L2]
|
Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells
,Son, YO;Pratheeshkumar, P;Divya, SP;Zhang, Z;Shi, X;,
J. Biol. Chem
,PubMed ID 28330870
[NFE2L2]
|
Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells
,Roy, RV;Pratheeshkumar, P;Son, YO;Wang, L;Hitron, JA;Divya, SP;Zhang, Z;Shi, X;,
Toxicol. Appl. Pharmacol.
,PubMed ID 27470422
[NFE2L2]
|
Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis
,Son, YO;Pratheeshkumar, P;Roy, RV;Hitron, JA;Wang, L;Divya, SP;Xu, M;Luo, J;Chen, G;Zhang, Z;Shi, X;,
J. Biol. Chem.
,PubMed ID 26385919
[NFE2L2]
|
ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell
,Chen, N;Wu, L;Yuan, H;Wang, J;,
Int. J. Biol. Sci.
,PubMed ID 26078725
[NFE2L2]
|
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