Txnip Mouse shRNA Plasmid (Locus ID 56338)
CAT#: TG503152
Txnip - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
Cited in 1 publication. |
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经常一起买 (1)
Specifications
Product Data | |
Product Name | Txnip Mouse shRNA Plasmid (Locus ID 56338) |
Locus ID | 56338 |
UniProt ID | Q8BG60 |
Synonyms | 1200008J08Rik; AA682105; Hyplip1; Tbp-2; THIF; VDUP1 |
Vector | pGFP-V-RS |
Format | Retroviral plasmids |
Kit Components | Txnip - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 56338). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
RefSeq | BC011212, BC031850, NM_001009935, NM_023719, NM_023719.1, NM_023719.2, NM_001009935.1, NM_001009935.2 |
Summary | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.[UniProtKB/Swiss-Prot Function] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury
,Genis, L;Dávila, D;Fernandez, S;,
FJan000Research, Jan 2014.
[Txnip]
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