Sema4a Mouse shRNA Plasmid (Locus ID 20351)
CAT#: TG510606
Sema4a - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
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Specifications
Product Data | |
Product Name | Sema4a Mouse shRNA Plasmid (Locus ID 20351) |
Locus ID | 20351 |
UniProt ID | Q62178 |
Synonyms | AI132332; Semab; SemB |
Vector | pGFP-V-RS |
Format | Retroviral plasmids |
Kit Components | Sema4a - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 20351). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
RefSeq | BC025800, NM_001163489, NM_001163490, NM_001163491, NM_013658, NM_001163489.1, NM_001163490.1, NM_013658.1, NM_013658.2, NM_013658.3, NM_001163491.1 |
Summary | Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (PubMed:20043131, PubMed:17318185). Regulates glutamatergic and GABAergic synapse development (PubMed:29981480). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (PubMed:29981480). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (PubMed:15780988). Promotes phosphorylation of TIMD2 (PubMed:12374982). Inhibits angiogenesis (PubMed:17318185). Promotes axon growth cone collapse (PubMed:20043131). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (PubMed:20043131).[UniProtKB/Swiss-Prot Function] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
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