Nos1ap Mouse shRNA Plasmid (Locus ID 70729)
CAT#: TL511126
Nos1ap - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
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CNY 7,740.00
货期*
2周
规格
Cited in 1 publication. |
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经常一起买 (3)
Specifications
Product Data | |
Product Name | Nos1ap Mouse shRNA Plasmid (Locus ID 70729) |
Locus ID | 70729 |
UniProt ID | Q9D3A8 |
Synonyms | 6330408P19Rik; Capon |
Vector | pGFP-C-shLenti |
Format | Lentiviral plasmids |
Kit Components | Nos1ap - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 70729). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
RefSeq | NM_001109985, NM_027528, NM_001109985.1, NM_027528.1, NM_027528.2, BC145237, BC160272, NM_001109985.2 |
Summary | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).[UniProtKB/Swiss-Prot Function] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.
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Science advances
,PubMed ID 33523862
[Nos1ap]
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