Rbm5 Rat shRNA Plasmid (Locus ID 300996)
CAT#: TL704115
Rbm5 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
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CNY 5,740.00
货期*
现货
规格
Cited in 2 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Product Name | Rbm5 Rat shRNA Plasmid (Locus ID 300996) |
Locus ID | 300996 |
UniProt ID | B2GV05 |
Vector | pGFP-C-shLenti |
Format | Lentiviral plasmids |
Kit Components | Rbm5 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 300996). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
RefSeq | NM_001100548, NM_001100548.1, BC089976, BC166477 |
Summary | Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity).[UniProtKB/Swiss-Prot Function] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (2)
The use of this RNAi has been cited in the following citations: |
---|
Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons
,Jackson, TC;Kotermanski, SE;Kochanek, PM;,
Neuroscience
,PubMed ID 28818525
[RBM5]
|
Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer.
,null,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
,PubMed ID 28347247
[Rbm5]
|
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