HHIP Human shRNA Plasmid Kit (Locus ID 64399)
CAT#: TR304118
HHIP - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
Cited in 2 publications. |
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经常一起买 (2)
Specifications
Product Data | |
Product Name | HHIP Human shRNA Plasmid Kit (Locus ID 64399) |
Locus ID | 64399 |
UniProt ID | Q96QV1 |
Synonyms | HIP |
Vector | pRS |
Format | Retroviral plasmids |
Kit Components | HHIP - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 64399). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
RefSeq | NM_022475, NM_022475.1, NM_022475.2, BC025311, BC025311.1, BC009298, BC015636, NM_022475.3 |
Summary | This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (2)
The use of this RNAi has been cited in the following citations: |
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Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms
,null,
Blood Cancer Journal
,PubMed ID 22961059
[HHIP]
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Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms
,M Kobune, S Iyama, S Kikuchi, H Horiguchi, T Sato, K Murase, Y Kawano, K Takada, K Ono, Y Kamihara, T Hayashi, K Miyanishi, Y Sato, R Takimoto & J Kato,
Blood Cancer Journal 2, e87 doi:10.1038/bcj.2012.36
[HHIP]
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