PON1 Human shRNA Plasmid Kit (Locus ID 5444)
CAT#: TR310286
PON1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
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CNY 6,790.00
货期*
2周
规格
Cited in 1 publication. |
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Specifications
Product Data | |
Product Name | PON1 Human shRNA Plasmid Kit (Locus ID 5444) |
Locus ID | 5444 |
UniProt ID | P27169 |
Synonyms | ESA; MVCD5; PON |
Vector | pRS |
Format | Retroviral plasmids |
Kit Components | PON1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5444). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
RefSeq | NM_000446, NM_000446.1, NM_000446.2, NM_000446.3, NM_000446.4, NM_000446.5, BC074719, BC074719.2, NM_000446.7 |
Summary | This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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Paraoxonase-1 (PON1) induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells
,Aldonza, MBD;Son, YS;Sung, HJ;Ahn, JM;Choi, YJ;Kim, YI;Cho, S;Cho, JY;,
Oncotarget
,PubMed ID 28467805
[PON1]
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