IFI16 Human shRNA Plasmid Kit (Locus ID 3428)
CAT#: TR312254
IFI16 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
Cited in 1 publication. |
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经常一起买 (2)
Specifications
Product Data | |
Product Name | IFI16 Human shRNA Plasmid Kit (Locus ID 3428) |
Locus ID | 3428 |
UniProt ID | Q16666 |
Synonyms | IFNGIP1; PYHIN2 |
Vector | pRS |
Format | Retroviral plasmids |
Kit Components | IFI16 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3428). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
RefSeq | NM_001206567, NM_005531, NM_005531.1, NM_005531.2, NM_001206567.1, BC017059, BM806453, BM993134, NM_001364867, NM_001206567.2 |
Summary | This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells
,Bosso, M;Prelli Bozzo, C;Hotter, D;Volcic, M;Stürzel, CM;Rammelt, A;Ni, Y;Urban, S;Becker, M;Schelhaas, M;Wittmann, S;Christensen, MH;Schmidt, FI;Gramberg, T;Sparrer, KMJ;Sauter, D;Kirchhoff, F;,
PLoS Pathog.
,PubMed ID 32760121
[IFI16]
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