Sort1 Mouse shRNA Plasmid (Locus ID 20661)
CAT#: TR502101
Sort1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
Cited in 1 publication. |
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经常一起买 (1)
Specifications
Product Data | |
Product Name | Sort1 Mouse shRNA Plasmid (Locus ID 20661) |
Locus ID | 20661 |
UniProt ID | Q6PHU5 |
Synonyms | 2900053A11Rik; AI852375; Ntr3; Ntsr3 |
Vector | pRS |
Format | Retroviral plasmids |
Kit Components | Sort1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 20661). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
RefSeq | BC056343, NM_001271599, NM_019972, NM_019972.1, NM_019972.2, NM_019972.3, NM_001271599.1, BC034129, BC099700 |
Summary | Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.[UniProtKB/Swiss-Prot Function] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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Sortilin regulates sorting and secretion of Sonic hedgehog
,Campbell, C;Beug, S;Nickerson, PE;Peng, J;Mazerolle, C;Bassett, E;Ringuette, R;Jama, FA;Morales, C;Christ, A;Wallace, VA;,
J. Cell. Sci.
,PubMed ID 27632999
[Sort1]
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