SIRT4 Human siRNA Oligo Duplex (Locus ID 23409)
CAT#: SR308254
SIRT4 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
Need single siRNA in bulk?
Get a free quote
CNY 4,090.00
货期*
4周
规格
Cited in 2 publications. |
Product images
![](https://cdn.origene.com/img/defaults-img.jpg)
经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_012240 |
Synonyms | SIR2L4 |
Components | SIRT4 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 23409)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (2)
The use of this RNAi has been cited in the following citations: |
---|
MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4
,Lang, A;Grether-Beck, S;Singh, M;Kuck, F;Jakob, S;Kefalas, A;Altinoluk-Hambüchen, S;Graffmann, N;Schneider, M;Lindecke, A;Brenden, H;Felsner, I;Ezzahoini, H;Marini, A;Weinhold, S;Vierkötter, A;Tigges, J;Schmidt, S;Stühler, K;Köhrer, K;Uhrberg, M;Haendeler, J;Krutmann, J;Piekorz, RP;,
Aging (Albany NY)
,PubMed ID 26959556
[SIRT4]
|
Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity
,null,
The Journal of Cell Biology
,PubMed ID 25023514
[SIRT4]
|
Documents
Product Manuals |
FAQs |
SDS |
Customer
Reviews
Loading...