Panx1 Mouse siRNA Oligo Duplex (Locus ID 55991)
CAT#: SR414119
Panx1 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 4 publications. |
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经常一起买 (2)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_019482 |
Synonyms | AI847747 |
Components | Panx1 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 55991)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity).[UniProtKB/Swiss-Prot Function] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (4)
The use of this RNAi has been cited in the following citations: |
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Connexin 43 hemichannels and pannexin-1 channels contribute to the α-synuclein-induced dysfunction and death of astrocytes
,Díaz, EF;Labra, VC;Alvear, TF;Mellado, LA;Inostroza, CA;Oyarzún, JE;Salgado, N;Quintanilla, RA;Orellana, JA;,
Glia
,PubMed ID 31033038
[PANX1]
|
Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function
,Sáez, JC;Contreras-Duarte, S;Gómez, GI;Labra, VC;Santibañez, CA;Gajardo-Gómez, R;Avendaño, BC;Díaz, EF;Montero, TD;Velarde, V;Orellana, JA;,
Front Immunol
,PubMed ID 30158937
[PANX1]
|
Cannabinoids prevent the amyloid ß-induced activation of astroglial hemichannels: A neuroprotective mechanism
,Gajardo-Gómez, R;Labra, VC;Maturana, CJ;Shoji, KF;Santibañez, CA;Sáez, JC;Giaume, C;Orellana, JA;,
Glia
,PubMed ID 27757991
[Panx1]
|
Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival
,Avendaño, BC;Montero, TD;Chávez, CE;von Bernhardi, R;Orellana, JA;,
Glia
,PubMed ID 26096155
[PANX1]
|
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