Adam17 Mouse siRNA Oligo Duplex (Locus ID 11491)
CAT#: SR420467
Adam17 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 35 publications. |
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经常一起买 (2)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001277266, NM_001291871, NM_009615, NR_102380, NR_120376 |
Synonyms | CD156b; Tac; Tace |
Components | Adam17 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 11491)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (35)
The use of this RNAi has been cited in the following citations: |
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Combination of natural polyphenols with a precursor of NAD + and a TLR2/6 ligand lipopeptide protects mice against lethal γ radiation
,null,
Journal of Advanced Research
,PubMed ID 35599107
[Adam17]
|
Estradiol inhibits HIV-1BaL infection and induces CFL1 expression in peripheral blood mononuclear cells and endocervical mucosa
,null,
Scientific Reports
,PubMed ID 35418661
[Adam17]
|
Desmoglein‐2 expression is an independent predictor of poor prognosis patients with multiple myeloma
,null,
Molecular Oncology
,PubMed ID 34245117
[Adam17]
|
Platelet isoform of phosphofructokinase promotes aerobic glycolysis and the progression of non-small cell lung cancer
,null,
Molecular Medicine Reports
,PubMed ID 33236133
[Adam17]
|
Knockdown of bone morphogenetic protein type II receptor leads to decreased aquaporin 1 expression and function in human pulmonary microvascular endothelial cells.
,null,
Canadian journal of physiology and pharmacology
,PubMed ID 32687728
[Adam17]
|
Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus
,null,
Nature Communications
,PubMed ID 32358486
[Adam17]
|
Spi-C positively regulates RANKL-mediated osteoclast differentiation and function
,null,
Experimental & Molecular Medicine
,PubMed ID 32341419
[Adam17]
|
Proteolytic Processing of Neuregulin 2
,Czarnek, M;Bereta, J;,
Mol. Neurobiol.
,PubMed ID 31838721
[ADAM17]
|
A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets. A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets
,null,
Physiological Reports
,PubMed ID 31591827
[Adam17]
|
CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation
,null,
Cancers
,PubMed ID 31627350
[Adam17]
|
Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer.
,null,
FEBS letters
,PubMed ID 31140586
[Adam17]
|
Type 2 diabetes‐induced hyposalivation of the submandibular gland through PINK1/Parkin‐mediated mitophagy, et al. Type 2 diabetes‐induced hyposalivation of the submandibular gland through PINK1/Parkin‐mediated mitophagy
,null,
Journal of Cellular Physiology
,PubMed ID 31190343
[Adam17]
|
Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells
,null,
The Journal of Neuroscience
,PubMed ID 30760627
[Adam17]
|
Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy
,null,
Autophagy
,PubMed ID 30289335
[Adam17]
|
Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium
,null,
American Journal of Physiology - Lung Cellular and Molecular Physiology
,PubMed ID 28971978
[Adam17]
|
Inflammatory Proteomic Network Analysis of Statin-treated and Lipopolysaccharide-activated Macrophages
,null,
Scientific Reports
,PubMed ID 29317699
[Adam17]
|
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation
,null,
Scientific Reports
,PubMed ID 29330382
[Adam17]
|
NF-κB-dependent upregulation of (pro)renin receptor mediates high-NaCl-induced apoptosis in mouse inner medullary collecting duct cells
,null,
American Journal of Physiology - Cell Physiology
,PubMed ID 29021196
[Adam17]
|
Identification of a cytogenetic and molecular subgroup of acute myeloid leukemias showing sensitivity to L-Asparaginase
,null,
Oncotarget
,PubMed ID 29299118
[Adam17]
|
Δ20 IFITM2 differentially restricts X4 and R5 HIV-1
,null,
Proceedings of the National Academy of Sciences of the United States of America
,PubMed ID 28630320
[Adam17]
|
Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2–mediated and prostaglandin E2–mediated pathways
,null,
Lipids in Health and Disease
,PubMed ID 27938411
[Adam17]
|
C3a Increases VEGF and Decreases PEDF mRNA Levels in Human Retinal Pigment Epithelial Cells
,null,
BioMed Research International
,PubMed ID 27747237
[Adam17]
|
Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells.
,null,
Biochemical and biophysical research communications
,PubMed ID 27221048
[Adam17]
|
Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability
,null,
Oncotarget
,PubMed ID 26625202
[Adam17]
|
Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations
,null,
Cancer research
,PubMed ID 26676756
[Adam17]
|
A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations
,null,
Oncotarget
,PubMed ID 25868979
[Adam17]
|
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
,null,
The Journal of Clinical Investigation
,PubMed ID 25798622
[Adam17]
|
BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization
,null,
The Journal of pathology
,PubMed ID 25408545
[Adam17]
|
CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3′ end processing
,null,
Nucleic Acids Research
,PubMed ID 24957598
[Adam17]
|
Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers
,null,
Oncotarget
,PubMed ID 25294805
[Adam17]
|
Uracil DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed
,null,
Molecular cancer therapeutics
,PubMed ID 23873851
[Adam17]
|
DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING
,null,
PLoS Pathogens
,PubMed ID 23055924
[Adam17]
|
MicroRNA-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer
,null,
Cancer research
,PubMed ID 23074286
[Adam17]
|
Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells
,null,
Cell Death and Differentiation
,PubMed ID 22261616
[Adam17]
|
MicroRNA-205 inhibits Src-mediated oncogenic pathways in renal cancer
,null,
Cancer research
,PubMed ID 21330408
[Adam17]
|
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