pCMV6-XL4 Mammalian Expression Vector
CNY 3,420.00
货期*
现货
规格
Cited in 904 publications. |
Specifications
Product Data | |
C-Tag | Tag Free |
E. coli Selection | Ampicillin (100 ug/mL) |
Storage | Store the vector DNA at -20°C |
Stability | Vector DNA is stable for at least one year from date of receipt when stored at -20°C |
Citations (904)
The use of this Vectors has been cited in the following citations: |
---|
Pharmacological targeting of androgen receptor elicits context-specific effects in estrogen receptor-positive breast cancer
,null,
Cancer research
,PubMed ID 36469363
|
The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells
,null,
Inflammation Research
,PubMed ID 37386145
|
A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds.
,null,
Acta pharmacologica Sinica
,PubMed ID 36114272
|
Therapeutic Effect of a Latent Form of Cortistatin in Experimental Inflammatory and Fibrotic Disorders
,null,
Pharmaceutics
,PubMed ID 36559278
|
Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency
,null,
Blood Advances
,PubMed ID 35839075
|
Downregulation of STAT3 in Epstein-Barr Virus-Positive Hodgkin Lymphoma
,null,
Biomedicines
,PubMed ID 35884913
|
5-Demethylnobiletin Inhibits Cell Proliferation, Downregulates ID1 Expression, Modulates the NF-κB/TNF-α Pathway and Exerts Antileukemic Effects in AML Cells
,null,
International Journal of Molecular Sciences
,PubMed ID 35806401
|
Proton export upregulates aerobic glycolysis
,null,
BMC Biology
,PubMed ID 35840963
|
How to avoid misinterpretation of dual reporter gene assay data affected by cell damage
,null,
Archives of Toxicology
,PubMed ID 35678845
|
Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers
,null,
Communications Biology
,PubMed ID 35654828
|
Halogenated bisphenol a analogues induce PPARγ-independent toxicity within human hepatocellular carcinoma cells
,null,
Current Research in Toxicology
,PubMed ID 35734227
|
Coordination of metal center biogenesis in human cytochrome c oxidase
,null,
Nature Communications
,PubMed ID 35750769
|
Endothelin-1 potentiates TRPV1-mediated vasoconstriction of human adipose arterioles in a protein kinase C-dependent manner
,null,
British journal of pharmacology
,PubMed ID 33184836
|
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior
,null,
eLife
,PubMed ID 35532105
|
Non‐enzymatic function of WRN RECQL helicase regulates removal of topoisomerase‐I‐DNA covalent complexes and triggers NF‐κB signaling in cancer). Non‐enzymatic function of WRN RECQL helicase regulates removal of topoisomerase‐I‐DNA covalent complexes and triggers NF‐κB signaling in cancer
,null,
Aging Cell
,PubMed ID 35582959
|
Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity
,null,
PLoS Pathogens
,PubMed ID 35584187
|
RASSF4 inhibits cell proliferation and increases drug sensitivity in colorectal cancer through YAP/Bcl‐2 pathway, et al. RASSF4 inhibits cell proliferation and increases drug sensitivity in colorectal cancer through YAP/Bcl‐2 pathway
,null,
Journal of Cellular and Molecular Medicine
,PubMed ID 35611809
|
CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons
,null,
Frontiers in Physiology
,PubMed ID 35620595
|
The Protein L-Isoaspartyl (D-Aspartyl) Methyltransferase Regulates Glial-to-Mesenchymal Transition and Migration Induced by TGF-β1 in Human U-87 MG Glioma Cells
,null,
International Journal of Molecular Sciences
,PubMed ID 35628507
|
Exosomal circRNA BTG2 derived from RBP-J overexpressed-macrophages inhibits glioma progression via miR-25-3p/PTEN
,null,
Cell Death & Disease
,PubMed ID 35643814
|
Mecp2 protects kidney from ischemia-reperfusion injury through transcriptional repressing IL-6/STAT3 signaling
,null,
Theranostics
,PubMed ID 35664078
|
Long Non-Coding RNA TMPO-AS1 Promotes GLUT1-Mediated Glycolysis and Paclitaxel Resistance in Endometrial Cancer Cells by Interacting With miR-140 and miR-143
,null,
Frontiers in Oncology
,PubMed ID 35712514
|
PDGF-R inhibition induces glioblastoma cell differentiation via DUSP1/p38MAPK signalling
,null,
Oncogene
,PubMed ID 35393545
|
The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion
,null,
PLoS Pathogens
,PubMed ID 35303042
|
Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia
,null,
Metabolites
,PubMed ID 35323704
|
Novel Cell-Based Assay for Alpha-3 Nicotinic Receptor Antibodies Detects Antibodies Exclusively in Autoimmune Autonomic Ganglionopathy
,null,
Neurology® Neuroimmunology & Neuroinflammation
,PubMed ID 35351814
|
FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells
,null,
Cells
,PubMed ID 35406686
|
Patchouli alcohol suppresses castration-resistant prostate cancer progression by inhibiting NF-κB signal pathways
,null,
Translational Andrology and Urology
,PubMed ID 35558260
|
Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells
,null,
JCI Insight
,PubMed ID 35015735
|
IBtkα Activates the β-Catenin-Dependent Transcription of MYC through Ubiquitylation and Proteasomal Degradation of GSK3β in Cancerous B Cells
,null,
International Journal of Molecular Sciences
,PubMed ID 35216159
|
Additive Effect of CD73 Inhibitor in Colorectal Cancer Treatment With CDK4/6 Inhibitor Through Regulation of PD-L1
,null,
Cellular and Molecular Gastroenterology and Hepatology
,PubMed ID 35843546
|
Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3
,null,
Cell Death & Disease
,PubMed ID 35013102
|
FOXO1 forkhead domain mutants in B-cell lymphoma lack transcriptional activity
,null,
Scientific Reports
,PubMed ID 35079069
|
Chitinase 3 like 1 is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability
,null,
Cardiovascular Research
,PubMed ID 33471078
|
Podocalyxin promotes an impermeable epithelium and inhibits pro-implantation factors to negatively regulate endometrial receptivity
,null,
Scientific Reports
,PubMed ID 34907278
|
Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation
,null,
Cellular and Molecular Life Sciences
,PubMed ID 34921637
|
Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis
,null,
Oncology Letters
,PubMed ID 34992682
|
AATF is Overexpressed in Human Head and Neck Squamous Cell Carcinoma and Regulates STAT3/Survivin Signaling
,null,
OncoTargets and therapy
,PubMed ID 34785906
|
TRAIL sensitivity of nasopharyngeal cancer cells involves redox dependent upregulation of TMTC2 and its interaction with membrane caspase-3
,null,
Redox Biology
,PubMed ID 34839142
|
Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation
,null,
Cellular and Molecular Gastroenterology and Hepatology
,PubMed ID 34655812
|
The effect of cullin 4A on lung cancer cell chemosensitivity to paclitaxel through p33ING1b regulation
,null,
American Journal of Translational Research
,PubMed ID 34786051
|
A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin
,null,
Aging (Albany NY)
,PubMed ID 34544906
|
Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy.
,null,
Cell biology and toxicology
,PubMed ID 34405320
|
Lamin B1 sequesters 53BP1 to control its recruitment to DNA damage
,null,
Science Advances
,PubMed ID 34452908
|
ADORA1 promotes nasopharyngeal carcinoma cell progression through regulation of PI3K/AKT/GSK-3β/β-catenin signaling
,null,
Life Sciences
,PubMed ID 33961854
|
Urocortin 3 overexpression reduces ER stress and heat shock response in 3T3-L1 adipocytes
,null,
Scientific Reports
,PubMed ID 34341463
|
Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration
,null,
Molecular Neurodegeneration
,PubMed ID 34344440
|
S100A4 is secreted by airway smooth muscle tissues and activates inflammatory signaling pathways via receptors for advanced glycation end products
,null,
American Journal of Physiology - Lung Cellular and Molecular Physiology
,PubMed ID 32432920
|
Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism
,null,
eNeuro
,PubMed ID 34135003
|
Del-1 enhances therapeutic efficacy of bacterial cancer immunotherapy by blocking recruitment of tumor-infiltrating neutrophils
,null,
Clinical and Translational Oncology
,PubMed ID 34236615
|
Human low-density lipoprotein receptor plays an important role in hepatitis B virus infection
,null,
PLoS Pathogens
,PubMed ID 34293069
|
Synthesis and Biological Evaluation of a Radiolabeled PET (Positron Emission Tomography) Probe for Visualization of In Vivo α-Fucosidase Expression
,null,
Pharmaceuticals
,PubMed ID 34451843
|
Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk
,null,
American Journal of Physiology - Heart and Circulatory Physiology
,PubMed ID 32196358
|
In vitro evidence suggesting that the toll-like receptor 7 and 8 agonist resiquimod (R-848) unlikely affects drug levels of co-administered compounds.
,null,
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
,PubMed ID 33813039
|
CXCL12 Retargeting of an Oncolytic Adenovirus Vector to the Chemokine CXCR4 and CXCR7 Receptors in Breast Cancer
,null,
Journal of cancer therapy
,PubMed ID 34178415
|
Sphingosine Kinase 1 Regulates the Pulmonary Vascular Immune Response
,null,
Cell Biochemistry and Biophysics
,PubMed ID 34133010
|
The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels
,null,
Frontiers in Pharmacology
,PubMed ID 34267666
|
CREG1 promotes lysosomal biogenesis and function
,null,
Autophagy
,PubMed ID 33966596
|
Phage display demonstrates durable differences in serological profile by route of inoculation in primary infections of non-human primates with Dengue Virus 1
,null,
Scientific Reports
,PubMed ID 34031504
|
Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine and CEN-092
,null,
Biochemistry and Biophysics Reports
,PubMed ID 34041373
|
Time-Resolved Effect of Interferon-Alpha 2a on Activities of Nuclear Factor Kappa B, Pregnane X Receptor and on Drug Disposition Genes
,null,
Pharmaceutics
,PubMed ID 34071580
|
Changes in SLIT2 expression are associated with the migration of human ovarian clear cell carcinoma cells
,null,
Oncology Letters
,PubMed ID 34093772
|
Inhibition of p22phox Suppresses Epithelial Ovarian Cancer Cell Proliferation and Tumorigenesis
,null,
Journal of Cancer
,PubMed ID 34093828
|
PWAR6 interacts with miR-106a-5p to regulate the osteogenic differentiation of human periodontal ligament stem cells
,null,
Molecular Medicine Reports
,PubMed ID 33576453
|
Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells
,null,
Autophagy
,PubMed ID 33849387
|
Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis
,null,
Redox Biology
,PubMed ID 33946018
|
Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1
,null,
World Journal of Gastroenterology
,PubMed ID 33958846
|
ZNF423 modulates the AMP-activated protein kinase pathway and metformin response in a single nucleotide polymorphisms, estrogen and selective estrogen receptor modulator dependent fashion
,null,
Pharmacogenetics and Genomics
,PubMed ID 34001842
|
A New Mouse Model Related to SCA14 Carrying a Pseudosubstrate Domain Mutation in PKCγ Shows Perturbed Purkinje Cell Maturation and Ataxic Motor Behavior
,null,
The Journal of Neuroscience
,PubMed ID 33478986
|
Soluble (Pro)Renin Receptor Induces Endothelial Dysfunction and Hypertension in Mice with Diet-Induced Obesity via Activation of Angiotensin II Type 1 Receptor
,null,
Clinical science (London, England : 1979)
,PubMed ID 33625485
|
Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer
,null,
Cell Death & Disease
,PubMed ID 33712558
|
Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
,null,
Communications Biology
,PubMed ID 33753867
|
Deficiency of cold‐inducible RNA‐binding protein exacerbated monocrotaline‐induced pulmonary artery hypertension through Caveolin1 and CAVIN1. Deficiency of cold‐inducible RNA‐binding protein exacerbated monocrotaline‐induced pulmonary artery hypertension through Caveolin1 and CAVIN1
,null,
Journal of Cellular and Molecular Medicine
,PubMed ID 33755319
|
A new TEX11 mutation causes azoospermia and testicular meiotic arrest
,null,
Asian Journal of Andrology
,PubMed ID 33762476
|
Transient Receptor Potential Ankyrin 1 (TRPA1)—An Inflammation-Induced Factor in Human HaCaT Keratinocytes
,null,
International Journal of Molecular Sciences
,PubMed ID 33805042
|
YTHDF1 Aggravates the Progression of Cervical Cancer Through m6A-Mediated Up-Regulation of RANBP2
,null,
Frontiers in Oncology
,PubMed ID 33816306
|
AHR Regulates NK Cell Migration via ASB2–Mediated Ubiquitination of Filamin A
,null,
Frontiers in Immunology
,PubMed ID 33717133
|
NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression
,Pang, J;Le, L;Zhou, Y;Tu, R;Hou, Q;Tsuchiya, D;Thomas, N;Wang, Y;Yu, Z;Alexander, R;Thexton, M;Lewis, B;Corbin, T;Durnin, M;Li, H;Ashery-Padan, R;Yan, D;Xie, T;,
Cell reports
,PubMed ID 33440163
[pCMV6XL4]
|
Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance
,Jersin, RÅ;Priyanka Tallapragada, DS;Madsen, A;Skartveit, L;Fjære, E;McCann, A;Dyer, L;Willems, A;Bjune, JI;Bjune, MS;Våge, V;Nielsen, HJ;Thorsen, HL;Nedrebø, BG;Busch, C;Steen, VM;Blüher, M;Jacobson, P;Svensson, PA;Fernø, J;Rydén, M;Arner, P;Nygård, O;Claussnitzer, M;Ellingsen, S;Madsen, L;Sagen, JV;Mellgren, G;Dankel, SN;,
Diabetes
,PubMed ID 33408126
[pCMV6-XL4]
|
Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice
,null,
International Journal of Molecular Sciences
,PubMed ID 33401680
|
JMJD8 Promotes Malignant Progression of Lung Cancer by Maintaining EGFR Stability and EGFR/PI3K/AKT Pathway Activation
,null,
Journal of Cancer
,PubMed ID 33442397
|
Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome
,null,
Frontiers in Physiology
,PubMed ID 33488405
|
Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner
,null,
Clinical Epigenetics
,PubMed ID 33499904
|
Differential activity and expression of human 5β-reductase (AKR1D1) splice variants
,null,
Journal of Molecular Endocrinology
,PubMed ID 33502336
|
MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma
,null,
Signal Transduction and Targeted Therapy
,PubMed ID 33262323
|
Proteasomal degradation of human SERINC4: A potent host anti-HIV-1 factor that is antagonized by nef
,null,
Current Research in Virological Science
,PubMed ID 33521797
|
DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma.
,null,
Oncogene
,PubMed ID 32071398
|
The GBA p.G85E mutation in Korean patients with non-neuronopathic Gaucher disease: founder and neuroprotective effects
,null,
Orphanet Journal of Rare Diseases
,PubMed ID 33176831
|
The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis
,null,
The Journal of Biological Chemistry
,PubMed ID 33199366
|
Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation
,null,
Cell Death and Differentiation
,PubMed ID 33230261
|
Therapeutic Potential Assessment of Green Synthesized Zinc Oxide Nanoparticles Derived from Fennel Seeds Extract
,AlSalhi, MS;Devanesan, S;Atif, M;AlQahtani, WS;Nicoletti, M;Serrone, PD;,
Int J Nanomedicine
,PubMed ID 33116517
[pCMV6-XL4]
|
A Zebrafish Model of Retinitis Pigmentosa Shows Continuous Degeneration and Regeneration of Rod Photoreceptors
,null,
Cells
,PubMed ID 33036185
|
Lysosomal-associated transmembrane protein 4B regulates ceramide-induced exosome release.
,null,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
,PubMed ID 33090522
|
Phospho-Mimetic Mutation at Ser602 Inactivates Human TRPA1 Channel
,null,
International Journal of Molecular Sciences
,PubMed ID 33121177
|
SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer
,null,
Scientific Reports
,PubMed ID 33122723
|
TRIP13 promotes the proliferation and invasion of lung cancer cells via the Wnt signaling pathway and epithelial-mesenchymal transition.
,null,
Journal of molecular histology
,PubMed ID 33128167
|
Role of ARID1A in epithelial‑mesenchymal transition in breast cancer and its effect on cell sensitivity to 5‑FU
,Wang, T;Gao, X;Zhou, K;Jiang, T;Gao, S;Liu, P;Zuo, X;Shi, X;,
International journal of molecular medicine
,PubMed ID 33000179
[pCMV6-XL4]
|
Consecutive Hypoxia Decreases Expression of NOTCH3 , HEY1 , CC10 , and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4 , NOTCH1 , MKI67 , OCT4 , and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells
,null,
Frontiers in Cell and Developmental Biology
,PubMed ID 33015064
|
An SCN1B Variant Affects Both Cardiac-Type (Na V 1.5) and Brain-Type (Na V 1.1) Sodium Currents and Contributes to Complex Concomitant Brain and Cardiac Disorders
,null,
Frontiers in Cell and Developmental Biology
,PubMed ID 33134290
|
MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by Activating WNT/β-Catenin Signal via ST7L
,null,
Technology in Cancer Research & Treatment
,PubMed ID 32924881
|
ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models
,null,
PLoS ONE
,PubMed ID 32970735
|
EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin αVβ3 in cancer cells
,null,
Cell Death Discovery
,PubMed ID 33014430
|
Decreased Expression of ZNF554 in Gliomas is Associated with the Activation of Tumor Pathways and Shorter Patient Survival
,null,
International Journal of Molecular Sciences
,PubMed ID 32796700
|
DNA Polyplexes of a Phosphorylcholine-Based Zwitterionic Polymer for Gene Delivery
,null,
Pharmaceutical research
,PubMed ID 32860072
|
Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo.
,null,
ACS chemical neuroscience
,PubMed ID 31034197
|
Human Cytomegalovirus (HCMV)-Specific Antibody Response and Development of Antibody-Dependent Cellular Cytotoxicity Against HCMV After Lung Transplantation.
,null,
The Journal of infectious diseases
,PubMed ID 32157310
|
Genetic variation in the farnesoid X-receptor predicts Crohn’s disease severity in female patients
,null,
Scientific Reports
,PubMed ID 32678214
|
Biochemical Characterization of Human Retroviral-Like Aspartic Protease 1 (ASPRV1)
,null,
Biomolecules
,PubMed ID 32640672
|
Characterization of guanine nucleotide exchange activity of DH domain of human FGD2.
,null,
Protein expression and purification
,PubMed ID 32681954
|
Identification and Expression of Several Circular RNAs and Knockdown of hsa_circ_0005556 Exerts Oncogenic Functions by miR-767-5p in Gastric Cancer
,null,
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
,PubMed ID 32728015
|
The Effects of Cannabidiol and Prognostic Role of TRPV2 in Human Endometrial Cancer
,null,
International Journal of Molecular Sciences
,PubMed ID 32751388
|
Reduced expression of odd-skipped related transcription factor 1 promotes proliferation and invasion of breast cancer cells and indicates poor patient prognosis
,null,
Oncology Letters
,PubMed ID 32782611
|
MicroRNA-301a promotes pancreatic cancer invasion and metastasis through the JAK/STAT3 signaling pathway by targeting SOCS5.
,null,
Carcinogenesis
,PubMed ID 31233116
|
Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon
,null,
Redox Biology
,PubMed ID 32604037
|
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome.
,null,
The Journal of experimental medicine
,PubMed ID 32207811
|
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity
,null,
Cell Death & Disease
,PubMed ID 32488063
|
A proopiomelanocortin‐derived peptide sequence enhances plasma stability of peptide drugs
,null,
FEBS Letters
,PubMed ID 32506501
|
FAM83G Is a Novel Inducer of Apoptosis
,null,
Molecules
,PubMed ID 32570757
|
Eicosapentaenoic acid’s metabolism of 15-LOX-1 promotes the expression of miR-101 thus inhibits Cox2 pathway in colon cancer
,null,
OncoTargets and therapy
,PubMed ID 32606775
|
DPAGT1‐Mediated Protein N‐Glycosylation Is Indispensable for Oocyte and Follicle Development in Mice, DPAGT1‐Mediated Protein N‐Glycosylation Is Indispensable for Oocyte and Follicle Development in Mice
,null,
Advanced Science
,PubMed ID 32714760
|
Molecular evolution of the proopiomelanocortin system in Barn owl species
,null,
PLoS ONE
,PubMed ID 32369484
|
Mutational analysis of SRD5A2: From gene to functional kinetics in individuals with steroid 5α-reductase 2 deficiency.
,null,
The Journal of steroid biochemistry and molecular biology
,PubMed ID 32380235
|
Genotype-phenotype analysis of LMNA-related diseases predicts phenotype-selective alterations in lamin phosphorylation.
,null,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
,PubMed ID 32413188
|
NADPH oxidase 1 is highly expressed in human large and small bowel cancers
,null,
PLoS ONE
,PubMed ID 32428030
|
Generation of Stable cisPt Resistant Lung Adenocarcinoma Cells
,null,
Pharmaceuticals
,PubMed ID 32485798
|
The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
,null,
Nucleic Acids Research
,PubMed ID 31996915
|
Enhanced Thermal Sensitivity of TRPV3 in Keratinocytes Underlies Heat-Induced Pruritogen Release and Pruritus in Atopic Dermatitis.
,null,
The Journal of investigative dermatology
,PubMed ID 32247859
|
Human DENND1A.V2 Drives Cyp17a1 Expression and Androgen Production in Mouse Ovaries and Adrenals
,null,
International Journal of Molecular Sciences
,PubMed ID 32268539
|
ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma
,Belisario, DC;Akman, M;Godel, M;Campani, V;Patrizio, MP;Scotti, L;Hattinger, CM;De Rosa, G;Donadelli, M;Serra, M;Kopecka, J;Riganti, C;,
Cells
,PubMed ID 32155954
[pCMV6-XL4]
|
Acid/bile exposure triggers TRAIL-mediated apoptosis in esophageal cancer cells by suppressing the decoy receptors and c-FLIPR.
,null,
The international journal of biochemistry cell biology
,PubMed ID 32135301
|
Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma
,null,
Cellular and Molecular Gastroenterology and Hepatology
,PubMed ID 32169577
|
Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness.
,null,
Expert opinion on therapeutic targets
,PubMed ID 32172636
|
Nobiletin, sinensetin, and tangeretin are the main perpetrators in clementines provoking food-drug interactions in vitro.
,null,
Food chemistry
,PubMed ID 32187570
|
Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of α7 Nicotinic Receptors in Mouse Brain?
,null,
Biomolecules
,PubMed ID 32204458
|
PIK3C3 Acts as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and Was Regulated by MiR-340-5p
,null,
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
,PubMed ID 32207410
|
RYBP inhibits esophageal squamous cell carcinoma proliferation through downregulating CDC6 and CDC45 in G1-S phase transition process.
,null,
Life sciences
,PubMed ID 32209426
|
Proximal C-Terminus Serves as a Signaling Hub for TRPA1 Channel Regulation via Its Interacting Molecules and Supramolecular Complexes
,null,
Frontiers in Physiology
,PubMed ID 32226391
|
Electrophysiological parameters that contribute to the pathogenesis of familial amyloid polyneuropathy caused by transthyretin mutations.
,null,
Journal of the neurological sciences
,PubMed ID 32247966
|
Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo
,Nikolaou, N;Arvaniti, A;Appanna, N;Sharp, A;Hughes, B;Digweed, D;Whitaker, M;Ross, RJ;Arlt, W;Penning, T;Morris, K;George, S;Keevil, B;Hodson, L;Gathercole, L;Tomlinson, JW;,
J. Endocrinol.
,PubMed ID 32106090
[pCMV6-XL4]
|
Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
,null,
Nature Communications
,PubMed ID 32041952
|
Redox Lipid Reprogramming Commands Susceptibility of Macrophages and Microglia to Ferroptotic Death.
,null,
Nature chemical biology
,PubMed ID 32080625
|
A Systematic Analysis Revealed the Potential Gene Regulatory Processes of ATRA-Triggered Neuroblastoma Differentiation and Identified a Novel RA Response Sequence in the NTRK2 Gene
,null,
BioMed Research International
,PubMed ID 32149119
|
Calcium-Inducible MAPK/AP-1 Signaling Drives Semaphorin 3A Expression in Normal Human Epidermal Keratinocytes.
,null,
The Journal of investigative dermatology
,PubMed ID 31945349
|
High Efficacy by GAL-021: A Known Intravenous Peripheral Chemoreceptor Modulator that Suppresses BK Ca -Channel Activity and Inhibits I K(M) or I h
,null,
Biomolecules
,PubMed ID 31991782
|
IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis.
,null,
Cell reports
,PubMed ID 30540936
|
Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytins
,null,
The Journal of Biological Chemistry
,PubMed ID 31735710
|
Autosomal recessive congenital cataracts linked to HSF4 in a consanguineous Pakistani family
,null,
PLoS ONE
,PubMed ID 31815953
|
Mitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells
,null,
Scientific Reports
,PubMed ID 31874991
|
Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage
,null,
Cells
,PubMed ID 31878344
|
Cytokine production capabilities of human primary monocyte-derived macrophages from patients with diabetes mellitus type 2 with and without diabetic peripheral neuropathy
,Alvarado-Vázquez, PA;Grosick, RL;Moracho-Vilrriales, C;Ward, E;Threatt, T;Romero-Sandoval, EA;,
J Pain Res
,PubMed ID 30588081
[pCMV6-XL4]
|
Hearing loss mutations alter the functional properties of human P2X2 receptor channels through distinct mechanisms
,null,
Proceedings of the National Academy of Sciences of the United States of America
,PubMed ID 31636190
|
Estrogen receptor α (ERα) indirectly induces transcription of human renal organic anion transporter 1 (OAT1). Estrogen receptor α (ERα) indirectly induces transcription of human renal organic anion transporter 1 (OAT1)
,null,
Physiological Reports
,PubMed ID 31724834
|
Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants
,null,
PLoS Genetics
,PubMed ID 31730647
|
PSMB10, the last immunoproteasome gene missing for PRAAS.
,null,
The Journal of allergy and clinical immunology
,PubMed ID 31783057
|
Analysis of NR5A1 in 142 patients with premature ovarian insufficiency, diminished ovarian reserve, or unexplained infertility.
,null,
Maturitas
,PubMed ID 31787151
|
CD163 overexpression using a macrophage-directed gene therapy approach improves wound healing in ex vivo and in vivo human skin models
,Ferreira, DW;Ulecia-Morón, C;Alvarado-Vázquez, PA;Cunnane, K;Moracho-Vilriales, C;Grosick, RL;Cunha, TM;Romero-Sandoval, EA;,
Immunobiology
,PubMed ID 31711674
[pCMV6-XL4]
|
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease
,null,
Metabolism
,PubMed ID 31330134
|
Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene
,null,
Molecular and Cellular Biology
,PubMed ID 31501275
|
The ubiquitin-like modifier FAT10 interferes with SUMO activation
,null,
Nature Communications
,PubMed ID 31575873
|
Induced Tamoxifen Resistance is Mediated by Increased Methylation of E-Cadherin in Estrogen Receptor-Expressing Breast Cancer Cells
,null,
Scientific Reports
,PubMed ID 31578396
|
Patchouli alcohol activates PXR and suppresses the NF-κB-mediated intestinal inflammatory.
,null,
Journal of ethnopharmacology
,PubMed ID 31614203
|
New rare genetic variants of LMF1 gene identified in severe hypertriglyceridemia.
,null,
Journal of clinical lipidology
,PubMed ID 30037590
|
BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells
,null,
Autophagy
,PubMed ID 31612776
|
Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases
,null,
Oncotarget
,PubMed ID 31645906
|
The Laminin Interactome: A Multifactorial Laminin-Binding Strategy by Nontypeable Haemophilus influenzae for Effective Adherence and Colonization
,null,
The Journal of Infectious Diseases
,PubMed ID 31034569
|
Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents
,null,
Cancers
,PubMed ID 31547492
|
Retinoblastoma binding protein 4 represses HIV-1 long terminal repeat-mediated transcription by recruiting NR2F1 and histone deacetylase
,Wang, J;Yang, Z;Cheng, L;Lu, L;Pan, K;Yang, J;Wu, N;,
Acta Biochim. Biophys. Sin. (Shanghai) 2019
,PubMed ID 31435636
[pCMV6-XL4]
|
The serine protease HtrA1 cleaves misfolded transforming growth factor β–induced protein (TGFBIp) and induces amyloid formation
,null,
The Journal of Biological Chemistry
,PubMed ID 31197037
|
Novel Cell-Based Assay for Identification of LRRK2 Inhibitors Using Its Aberrant Regulation of a Pluripotency Gene.
,null,
SLAS discovery : advancing life sciences R D
,PubMed ID 31373835
|
Increased clusterin levels after myocardial infarction is due to a defect in protein degradation systems activity
,null,
Cell Death & Disease
,PubMed ID 31406108
|
Upregulation of Myc promotes the evasion of NK cell-mediated immunity through suppression of NKG2D ligands in K562 cells
,null,
Molecular Medicine Reports
,PubMed ID 31432134
|
Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma.
,null,
Cellular immunology
,PubMed ID 31472938
|
Protein kinase CK2 subunits exert specific and coordinated functions in skeletal muscle differentiation and fusogenic activity
,null,
The FASEB Journal
,PubMed ID 31268746
|
An exploration of conditions proposed to trigger the Ebola virus glycoprotein for fusion
,null,
PLoS ONE
,PubMed ID 31276481
|
Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP
,null,
International Journal of Molecular Sciences
,PubMed ID 31357561
|
Proteomic analysis reveals a role for PAX8 in peritoneal colonization of high grade serous ovarian cancer that can be targeted with micelle encapsulated thiostrepton
,Hardy, LR;Pergande, MR;Esparza, K;Heath, KN;Önyüksel, H;Cologna, SM;Burdette, JE;,
Oncogene
,PubMed ID 31296958
[pCMV6-XL4]
|
Putative interaction site for membrane phospholipids controls activation of TRPA1 channel at physiological membrane potentials.
,null,
The FEBS journal
,PubMed ID 31116904
|
Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia
,null,
Lipids in Health and Disease
,PubMed ID 31164121
|
Open reading frame mining identifies a TLR4 binding domain in the primary sequence of ECRG4.
,null,
Cellular and molecular life sciences : CMLS
,PubMed ID 31190084
|
Lack of zinc finger protein 521 upregulates dopamine β-hydroxylase expression in the mouse brain, leading to abnormal behavior.
,null,
Life sciences
,PubMed ID 31200001
|
The sigma‐1 receptor behaves as an atypical auxiliary subunit to modulate the functional characteristics of Kv1.2 channels expressed in HEK293 cells. The sigma‐1 receptor behaves as an atypical auxiliary subunit to modulate the functional characteristics of Kv1.2 channels expressed in HEK293 cells
,null,
Physiological Reports
,PubMed ID 31222975
|
Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP
,null,
eLife
,PubMed ID 31232692
|
Keratin 6, induced by chronic cisplatin exposure, confers chemoresistance in human gastric carcinoma cells.
,null,
Oncology reports
,PubMed ID 31233200
|
FOXA1 mutations alter pioneering activity, differentiation, and prostate cancer phenotypes
,null,
Nature
,PubMed ID 31243370
|
Using PU.1 and Jun dimerization protein 2 transcription factor expression in myelodysplastic syndromes to predict treatment response and leukaemia transformation.
,null,
Annals of hematology
,PubMed ID 30721335
|
AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer
,Collina, F;La Sala, L;Liotti, F;Prevete, N;La Mantia, E;Chiofalo, MG;Aquino, G;Arenare, L;Cantile, M;Liguori, G;Di Gennaro, F;Pezzullo, L;Losito, NS;Vecchio, G;Botti, G;Melillo, RM;Franco, R;,
Cancers (Basel) 2019
,PubMed ID 31181609
[pCMV6-XL4]
|
Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T > C nonsynonymous single-nucleotide polymorphism
,null,
Pharmaceutical research
,PubMed ID 31093828
|
Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly
,null,
BMC Biology
,PubMed ID 31118010
|
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway
,null,
Cells
,PubMed ID 31146385
|
Deregulated expression of NKL homeobox genes in T-cell lymphomas
,null,
Oncotarget
,PubMed ID 31143370
|
Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma
,Hald, ØH;Olsen, L;Gallo-Oller, G;Elfman, LHM;Løkke, C;Kogner, P;Sveinbjörnsson, B;Flægstad, T;Johnsen, JI;Einvik, C;,
Oncogene
,PubMed ID 30542116
[pCMV-XL4]
|
Identification of rare variants in cardiac sodium channel β4‑subunit gene SCN4B associated with ventricular tachycardia
,null,
Molecular genetics and genomics : MGG
,PubMed ID 31020414
|
Down-Regulation of MHC Class I Expression in Human Keratinocytes Using Viral Vectors Containing US11 Gene of Human Cytomegalovirus and Cultivation on Bovine Collagen-Elastin Matrix (Matriderm®): Potential Approach for an Immune-Privileged Skin Substitute
,null,
International Journal of Molecular Sciences
,PubMed ID 31027326
|
The mitochondrial metabolic function of DJ-1 is modulated by 14-3-3β
,null,
The FASEB Journal
,PubMed ID 31034784
|
Harmine induces anticancer activity in breast cancer cells via targeting TAZ
,null,
International Journal of Oncology
,PubMed ID 31081045
|
Quantification of the Lamin A/C Transcript Variants in Cancer Cell Lines by Targeted Absolute Quantitative Proteomics and Correlation with mRNA Expression
,Al-Qahtani, WS;Abduljabbar, M;AlSuhaibani, ES;Abel Rahman, A;Aljada, A;,
Int J Mol Sci
,PubMed ID 30999625
[pCMV6-XL4]
|
RAD9A promotes metastatic phenotypes through transcriptional regulation of anterior gradient 2 (AGR2)
,null,
Carcinogenesis
,PubMed ID 30295739
|
Toll-Like Receptor 4 Activation Promotes Multiple Myeloma Cell Growth and Survival Via Suppression of The Endoplasmic Reticulum Stress Factor Chop
,null,
Scientific Reports
,PubMed ID 30824741
|
Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas.
,null,
Nature medicine
,PubMed ID 30833747
|
Simultaneous induction of distinct protein phase separation events in multiple subcellular compartments of a single cell.
,null,
Experimental cell research
,PubMed ID 30851242
|
Ornithine transcarbamylase downregulation is associated with poor prognosis in hepatocellular carcinoma
,null,
Oncology Letters
,PubMed ID 31186714
|
Ornithine transcarbamylase downregulation is associated with poor prognosis in hepatocellular carcinoma
,He, L;Cai, X;Cheng, S;Zhou, H;Zhang, Z;Ren, J;Ren, F;Yang, Q;Tao, N;Chen, J;,
Oncol Lett
[pCMV6-XL4]
|
Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice
,null,
Molecular Neurodegeneration
,PubMed ID 30832693
|
Hepatic HKDC1 Expression Contributes to Liver Metabolism
,null,
Endocrinology
,PubMed ID 30517626
|
The catalytic, stem, and transmembrane portions of matriptase-2 are required for suppressing the expression of the iron-regulatory hormone hepcidin
,null,
The Journal of Biological Chemistry
,PubMed ID 30559294
|
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53
,null,
Journal of Experimental & Clinical Cancer Research : CR
,PubMed ID 30755245
|
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells
,null,
The Journal of steroid biochemistry and molecular biology
,PubMed ID 30769091
|
Further corroboration of distinct functional features in SCN2A variants causing intellectual disability or epileptic phenotypes
,null,
Molecular Medicine
,PubMed ID 30813884
|
Muscleblind‑like 1 destabilizes Snail mRNA and suppresses the metastasis of colorectal cancer cells via the Snail/E‑cadherin axis
,Tang, L;Zhao, P;Kong, D;,
Int. J. Oncol.
,PubMed ID 30664186
[PCMV6-XL4]
|
Perilipin-2 is critical for efficient lipoprotein and hepatitis C virus particle production.
,null,
Journal of cell science
,PubMed ID 30559250
|
Role of FOXC2 and PITX2 rare variants associated with mild functional alterations as modifier factors in congenital glaucoma
,null,
PLoS ONE
,PubMed ID 30657791
|
A bioactive nano-calcium phosphate paste for in-situ transfection of BMP-7 and VEGF-A in a rabbit critical-size bone defect: results of an in vivo study.
,null,
Journal of materials science. Materials in medicine
,PubMed ID 30671652
|
Melanocortin-1 Receptor Positively Regulates Human Artery Endothelial Cell Migration.
,null,
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
,PubMed ID 31050282
|
Monitoring Antigen Processing for MHC Presentation via Macroautophagy.
,null,
Methods in molecular biology (Clifton, N.J.)
,PubMed ID 31147952
|
Decreased RNF41 expression leads to insulin resistance in skeletal muscle of obese women.
,null,
Metabolism: clinical and experimental
,PubMed ID 29410345
|
Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease.
,null,
Human molecular genetics
,PubMed ID 30239752
|
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells
,null,
Cell Chemical Biology
,PubMed ID 30293938
|
IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity
,null,
International journal of obesity (2005)
,PubMed ID 30538277
|
Transfection of T-Box Transcription Factor BRACHYURY and SOX2 Synergistically Promote Self-Renewal and Invasive Phenotype in Oral Cancer Cells
,null,
International Journal of Molecular Sciences
,PubMed ID 30453543
|
Inflammasome-Independent Role of NLRP3 Mediates Mitochondrial Regulation in Renal Injury
,null,
Frontiers in Immunology
,PubMed ID 30483252
|
Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABAA-ergic systems: Involvement of 5-HT1A receptor agonistic activity.
,null,
Biomedicine pharmacotherapy = Biomedecine pharmacotherapie
,PubMed ID 30551479
|
TBX2 overexpression promotes proliferation and invasion through epithelial-mesenchymal transition and ERK signaling pathway
,null,
Experimental and Therapeutic Medicine
,PubMed ID 30651856
|
Hippo kinase NDR2 inhibits IL-17 signaling by promoting Smurf1-mediated MEKK2 ubiquitination and degradation
,Ma, X;Wang, D;Li, N;Gao, P;Zhang, M;Zhang, Y;,
Molecular immunology
,PubMed ID 30504095
[pCMV6-XL4]
|
The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation
,null,
American Journal of Physiology - Cell Physiology
,PubMed ID 30020827
|
NKL homeobox gene activities in B-cell development and lymphomas
,null,
PLoS ONE
,PubMed ID 30308041
|
The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes
,null,
Diabetologia
,PubMed ID 30338340
|
Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia
,null,
Scientific Reports
,PubMed ID 30375486
|
The Regulation of Cbf1 by PAS Kinase Is a Pivotal Control Point for Lipogenesis vs. Respiration in Saccharomyces cerevisiae
,null,
G3: Genes|Genomes|Genetics
,PubMed ID 30381292
|
Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodiumâÂÂinduced colitis in mice
,null,
British Journal of Pharmacology
,PubMed ID 29945292
|
S100A4 Knockout Sensitizes Anaplastic Thyroid Carcinoma Cells Harboring BRAFV600E/Mt to Vemurafenib.
,null,
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
,PubMed ID 30196299
|
UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy
,null,
Brain
,PubMed ID 30239612
|
Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis
,null,
Cell Death & Disease
,PubMed ID 30250075
|
The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells
,null,
Neoplasia (New York, N.Y.)
,PubMed ID 30265861
|
CCN1 induces apoptosis in esophageal adenocarcinoma through p53-dependent downregulation of survivin.
,null,
Journal of cellular biochemistry
,PubMed ID 30318638
|
A method using angiotensin converting enzyme immobilized on magnetic beads for inhibitor screening.
,null,
Journal of pharmaceutical and biomedical analysis
,PubMed ID 30391811
|
Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency
,null,
Journal of Virology
,PubMed ID 30089695
|
Interference with NTSR1 Expression Exerts an Anti-Invasion Effect via the Jun/miR-494/SOCS6 Axis of Glioblastoma Cells
,Ou-Yang, Q;He, X;Yang, A;Li, B;Xu, M;,
Cell. Physiol. Biochem.
,PubMed ID 30261490
[pCMV6-XL4]
|
Synovial GATA1 mediates rheumatoid arthritis progression via transcriptional activation of NOS2 signaling.
,null,
Microbiology and immunology
,PubMed ID 29993142
|
A novel ZIC3 gene mutation identified in patients with heterotaxy and congenital heart disease
,null,
Scientific Reports
,PubMed ID 30120289
|
GPR40 is a low-affinity epoxyeicosatrienoic acid receptor in vascular cells
,null,
The Journal of Biological Chemistry
,PubMed ID 29777058
|
Decline in arylsulfatase B expression increases EGFR expression by inhibiting the protein-tyrosine phosphatase SHP2 and activating JNK in prostate cells
,null,
The Journal of Biological Chemistry
,PubMed ID 29794138
|
miR-331-3p functions as an oncogene by targeting ST7L in pancreatic cancer.
,null,
Carcinogenesis
,PubMed ID 29850766
|
Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function
,null,
The Journal of General Physiology
,PubMed ID 29853476
|
PAPPA2 as a Therapeutic Modulator of IGF-I Bioavailability: in Vivo and in Vitro Evidence
,null,
Journal of the Endocrine Society
,PubMed ID 29942928
|
Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention
,null,
The Journal of Neuroscience
,PubMed ID 29967007
|
CD177-mediated nanoparticle targeting of human and mouse neutrophils
,null,
PLoS ONE
,PubMed ID 29990379
|
Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking
,null,
JCI Insight
,PubMed ID 30046013
|
Type 2 Diabetes Risk Alleles in PAM Impact Insulin Release from Human Pancreatic Beta Cells
,null,
Nature genetics
,PubMed ID 30054598
|
Impact of OGT deregulation on EZH2 target genes FOXA1 and FOXC1 expression in breast cancer cells
,null,
PLoS ONE
,PubMed ID 29864144
|
Ubiquitin-Dependent Degradation of Mitochondrial Proteins Regulates Energy Metabolism.
,null,
Cell reports
,PubMed ID 29874573
|
Mutational and functional studies on NR5A1 gene in 46,XY disorders of sex development: identification of six novel loss of function mutations.
,null,
Fertility and sterility
,PubMed ID 29935645
|
CRP Stimulates GDF15 Expression in Endothelial Cells through p53
,null,
Mediators of Inflammation
,PubMed ID 29967567
|
Comparative Assessment on the Expression Level of Recombinant Human Follicle-Stimulating Hormone (FSH) in Serum-Containing Versus Protein-Free Culture Media.
,null,
Molecular biotechnology
,PubMed ID 28993982
|
Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition
,null,
Frontiers in Immunology
,PubMed ID 29896202
|
Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor
,null,
Blood Advances
,PubMed ID 29632235
|
The effect of NR4A1 on APP metabolism and tau phosphorylation
,null,
Genes & Diseases
,PubMed ID 30591936
|
Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn’s disease
,null,
The Journal of Clinical Investigation
,PubMed ID 29408806
|
Histone-Targeted Gene Transfer of Bone Morphogenetic Protein-2 Enhances Mesenchymal Stem Cell Chondrogenic Differentiation
,null,
Acta biomaterialia
,PubMed ID 29481871
|
MicroRNA-622 is a novel mediator of tumorigenicity in melanoma by targeting Kirsten rat sarcoma.
,null,
Pigment cell melanoma research
,PubMed ID 29495114
|
Studying the mechanism of PLAGL2 overexpression and its carcinogenic characteristics based on 3′-untranslated region in colorectal cancer
,null,
International Journal of Oncology
,PubMed ID 29512763
|
Cystatin C promotes tau protein phosphorylation and causes microtubule instability by inhibiting intracellular turnover of GSK3β in neurons.
,null,
Molecular and cellular neurosciences
,PubMed ID 29577984
|
VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites
,null,
Blood Advances
,PubMed ID 29581108
|
Helicobacter pylori induces somatic mutations in TP53 via overexpression of CHAC1 in infected gastric epithelial cells
,null,
FEBS Open Bio
,PubMed ID 29632819
|
Neurotensin receptor type 2 protects B-cell chronic lymphocytic leukemia cells from apoptosis
,null,
Oncogene
,PubMed ID 29059151
|
Probing ligand structure-activity relationships in pregnane X receptor (PXR): efavirenz and 8-hydroxyefavirenz exhibit divergence in activation
,Narayanan, B;Lade, J;Heck, CJS;Dietz, KD;Wade, HV;Bumpus, NN;,
ChemMedChem
,PubMed ID 29430850
[pCMV6-XL4]
|
De novo mutations implicate novel genes in systemic lupus erythematosus
,null,
Human Molecular Genetics
,PubMed ID 29177435
|
Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity
,null,
The Journal of Biological Chemistry
,PubMed ID 29259132
|
Molecular mechanisms of cutis laxa– and distal renal tubular acidosis–causing mutations in V-ATPase a subunits, ATP6V0A2 and ATP6V0A4
,null,
The Journal of Biological Chemistry
,PubMed ID 29311258
|
Identification of FAM173B as a protein methyltransferase promoting chronic pain
,null,
PLoS Biology
,PubMed ID 29444090
|
Artemin regulates CXCR4 expression to induce migration and invasion in pancreatic cancer cells through activation of NF-κB signaling.
,null,
Experimental cell research
,PubMed ID 29453972
|
c-Jun/AP-1 overexpression reprograms ERα signaling related to tamoxifen response in ERα-positive breast cancer.
,null,
Oncogene
,PubMed ID 29467493
|
Nonketotic hyperglycinemia: Functional assessment of missense variants in GLDC to understand phenotypes of the disease.
,null,
Human mutation
,PubMed ID 28244183
|
Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling
,Senavirathna, LK;Huang, C;Yang, X;Munteanu, MC;Sathiaseelan, R;Xu, D;Henke, CA;Liu, L;,
Sci Rep
,PubMed ID 29426911
[PCMV6-XL4]
|
Insights into the role of ribonuclease 4 polymorphisms in amyotrophic lateral sclerosis.
,null,
Journal of biomolecular structure dynamics
,PubMed ID 29279004
|
Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation
,null,
EMBO Reports
,PubMed ID 29335246
|
Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel.
,null,
Science signaling
,PubMed ID 29363587
|
Decreased ZONAB expression promotes excessive transdifferentiation of alveolar epithelial cells in hyperoxia-induced bronchopulmonary dysplasia.
,null,
International journal of molecular medicine
,PubMed ID 29393348
|
Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa
,null,
Drug Metabolism and Disposition
,PubMed ID 29691238
|
Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell function
,Josipovic, I;Pflüger, B;Fork, C;Vasconez, AE;Oo, JA;Hitzel, J;Seredinski, S;Gamen, E;Heringdorf, DMZ;Chen, W;Looso, M;Pullamsetti, SS;Brandes, RP;Leisegang, MS;,
J. Mol. Cell. Cardiol.
,PubMed ID 29408197
[PCMV6-XL4]
|
A Highly Productive CHO Cell Line Secreting Human Blood Clotting Factor IX
,null,
Acta Naturae
,PubMed ID 29713519
|
Acute exposure to high‐induction electromagnetic field affects activity of model peripheral sensory neurons
,null,
Journal of Cellular and Molecular Medicine
,PubMed ID 29210178
|
Functional characterization of the G162R and D216H genetic variants of human CYP17A1
,null,
The Journal of steroid biochemistry and molecular biology
,PubMed ID 29229304
|
HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway
,null,
Stem Cell Reports
,PubMed ID 29249663
|
Insulin-like growth factor-I induces chemoresistence to docetaxel by inhibiting miR-143 in human prostate cancer
,null,
Oncotarget
,PubMed ID 29291019
|
Histone Deacetylase 5 is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repressing Pro-angiogenic Factors
,null,
Arthritis & rheumatology (Hoboken, N.J.)
,PubMed ID 27482699
|
Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway
,null,
The Journal of Biological Chemistry
,PubMed ID 28924039
|
Overexpression of lamin B1 induces mitotic catastrophe in colon cancer LoVo cells and is associated with worse clinical outcomes
,null,
International Journal of Oncology
,PubMed ID 29115590
|
A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
,null,
Scientific Reports
,PubMed ID 29123178
|
Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation
,null,
eLife
,PubMed ID 29143738
|
Regulatory T cells control toxicity in a humanized model of IL-2 therapy
,null,
Nature Communications
,PubMed ID 29176694
|
Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3)
,null,
Oncotarget
,PubMed ID 29245974
|
Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers
,null,
Oncotarget
,PubMed ID 29262535
|
CCN1 sensitizes esophageal cancer cells to TRAIL-mediated apoptosis.
,null,
Experimental cell research
,PubMed ID 29055676
|
NEAT1 regulates cell proliferation and apoptosis of ovarian cancer by miR-34a-5p/BCL2
,null,
OncoTargets and therapy
,PubMed ID 29062236
|
Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition.
,null,
Biochimica et biophysica acta. Molecular cell research
,PubMed ID 29100790
|
The coiled-coil domain of oncogene RASSF 7 inhibits hippo signaling and promotes non-small cell lung cancer
,null,
Oncotarget
,PubMed ID 29108261
|
c-Fos mediates α1, 2-fucosyltransferase 1 and Lewis y expression in response to TGF-β1 in ovarian cancer
,null,
Oncology Reports
,PubMed ID 29130097
|
Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice
,null,
American Journal of Physiology - Endocrinology and Metabolism
,PubMed ID 28655716
|
Regulation of the epithelial Na+ channel by paraoxonase-2
,null,
The Journal of Biological Chemistry
,PubMed ID 28768768
|
BLM and SLX4 play opposing roles in recombination‐dependent replication at human telomeres
,null,
The EMBO Journal
,PubMed ID 28877996
|
Identification of GPC2 as an oncoprotein and candidate immunotherapeutic target in high-risk neuroblastoma
,null,
Cancer cell
,PubMed ID 28898695
|
Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex
,null,
Scientific Reports
,PubMed ID 28912501
|
Overexpression of stathmin plays a pivotal role in the metastasis of esophageal squamous cell carcinoma
,null,
Oncotarget
,PubMed ID 28977901
|
TRIM22 confers poor prognosis and promotes epithelial-mesenchymal transition through regulation of AKT/GSK3β/β-catenin signaling in non-small cell lung cancer
,null,
Oncotarget
,PubMed ID 28977927
|
NKL homeobox gene MSX1 acts like a tumor suppressor in NK-cell leukemia
,null,
Oncotarget
,PubMed ID 28977998
|
Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants
,Mao, G;Songdej, N;Voora, D;Goldfinger, LE;Del Carpio-Cano, FE;Myers, RA;Rao, AK;,
Circulation
,PubMed ID 28676520
[PCMV6-XL4]
|
Mast cell degranulation via MRGPRX2 by isolated human albumin fragments.
,null,
Biochimica et biophysica acta. General subjects
,PubMed ID 28844982
|
Role of S100A9 in the development of neutrophilic inflammation in asthmatics and in a murine model.
,null,
Clinical immunology (Orlando, Fla.)
,PubMed ID 28847516
|
Modification of Human Umbilical Cord Blood Stem Cells Using Polyethylenimine Combined with Modified TAT Peptide to Enhance BMP-2 Production
,null,
BioMed Research International
,PubMed ID 28951869
|
N-linked glycosylation of a subunit isoforms is critical for vertebrate vacuolar H+ -ATPase (V-ATPase) biosynthesis.
,null,
Journal of cellular biochemistry
,PubMed ID 28661051
|
A TBX5 3′UTR variant increases the risk of congenital heart disease in the Han Chinese population
,null,
Cell Discovery
,PubMed ID 28761722
|
Molecular Characterization of Somatic Alterations in Dukes’ B and C Colorectal Cancers by Targeted Sequencing
,null,
Frontiers in Pharmacology
,PubMed ID 28769798
|
Agonist-dependence of functional properties for common nonsynonymous variants of human transient receptor potential vanilloid 1
,null,
Pain
,PubMed ID 26967694
|
The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer
,null,
Oncotarget
,PubMed ID 28574829
|
Bcl3: a regulator of NF-κB inducible by TWEAK in acute kidney injury with anti-inflammatory and antiapoptotic properties in tubular cells
,null,
Experimental & Molecular Medicine
,PubMed ID 28684863
|
MicroRNA-136 inhibits colon cancer cell proliferation and invasion through targeting liver receptor homolog-1/Wnt signaling.
,null,
Gene
,PubMed ID 28710032
|
Human papillomavirus type 8 E7 protein binds nuclear myosin 1c and downregulates the expression of pre-rRNA.
,null,
Virus genes
,PubMed ID 28733876
|
Increased biological activity of protein Kinase C gamma is not required in Spinocerebellar ataxia 14
,null,
Molecular Brain
,PubMed ID 28738819
|
URI promotes the migration and invasion of human cervical cancer cells potentially via upregulation of vimentin expression
,null,
American Journal of Translational Research
,PubMed ID 28670391
|
The DEAD-box RNA helicase DDX41 is a novel repressor of p21WAF1/CIP1 mRNA translation
,null,
The Journal of Biological Chemistry
,PubMed ID 28348086
|
A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5.
,null,
Journal of medicinal chemistry
,PubMed ID 28441491
|
The critical role of Nramp1 in degrading α-synuclein oligomers in microglia under iron overload condition.
,null,
Neurobiology of disease
,PubMed ID 28476637
|
GAB2 regulates type 2 T helper cell differentiation in humans.
,null,
Cytokine
,PubMed ID 28477539
|
Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6.
,null,
Hormones cancer
,PubMed ID 28516379
|
Macrophage-specific nanotechnology driven CD163 overexpression in human macrophages results in an M2 phenotype under inflammatory conditions
,null,
Immunobiology
,PubMed ID 28545809
|
A functional DC cross talk promotes human ILC homeostasis in humanized mice
,null,
Blood Advances
,PubMed ID 29296702
|
Dysregulation of PLDN (pallidin) is a mechanism for platelet dense granule deficiency in RUNX1 haplodeficiency
,Mao, GF;Goldfinger, LE;Fan, DC;Lambert, MP;Jalagadugula, G;Freishtat, R;Rao, AK;,
J. Thromb. Haemost.
,PubMed ID 28075530
[pCMV6-XL4]
|
Bortezomib and ixazomib protect firefly luciferase from degradation and can flaw respective reporter gene assays.
,null,
Analytical biochemistry
,PubMed ID 27325500
|
Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease
,null,
Human Molecular Genetics
,PubMed ID 28175299
|
Nanobodies against surface biomarkers enable the analysis of tumor genetic heterogeneity in uveal melanoma patient-derived xenografts.
,null,
Pigment cell melanoma research
,PubMed ID 28140525
|
Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity
,null,
Molecular and Cellular Biology
,PubMed ID 28167606
|
Down-Regulation of MicroRNA-210 Confers Sensitivity towards 1’S-1’-Acetoxychavicol Acetate (ACA) in Cervical Cancer Cells by Targeting SMAD4
,null,
Molecules and Cells
,PubMed ID 28401751
|
Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions
,null,
Oncotarget
,PubMed ID 28412746
|
Upregulation of miRNA-4776 in Influenza Virus Infected Bronchial Epithelial Cells Is Associated with Downregulation of NFKBIB and Increased Viral Survival
,null,
Viruses
,PubMed ID 28448456
|
Simvastatin-Induced Sphingosine 1− Phosphate Receptor 1 Expression is KLF2-Dependent in Human Lung Endothelial Cells
,Sun, X;Mathew, B;Sammani, S;Jacobson, JR;Garcia, JG;,
Pulmonary Circulation
[PCMV6-XL4]
|
Differential activation of pregnane X receptor by carnosic acid, carnosol, ursolic acid, and rosmarinic acid
,Seow, CL;Lau, AJ;,
Pharmacol. Res
,PubMed ID 28288941
[pCMV6-XL4]
|
O-Linked N-Acetylglucosamine (O-GlcNAc) Expression Levels Epigenetically Regulate Colon Cancer Tumorigenesis by Affecting the Cancer Stem Cell Compartment via Modulating Expression of Transcriptional Factor MYBL1 *
,null,
The Journal of Biological Chemistry
,PubMed ID 28096468
|
A variant in a cis-regulatory element enhances claudin-14 expression and is associated with pediatric-onset hypercalciuria and kidney stones.
,null,
Human mutation
,PubMed ID 28229505
|
Upregulation of the endothelin A (ETA) receptor and its association with neurodegeneration in a rodent model of glaucoma
,null,
BMC Neuroscience
,PubMed ID 28249604
|
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters
,null,
Journal of medicinal chemistry
,PubMed ID 28319392
|
A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population
,null,
PLoS ONE
,PubMed ID 28334007
|
Suppression of microRNA-629 enhances sensitivity of cervical cancer cells to 1′S-1′-acetoxychavicol acetate via regulating RSU1
,null,
OncoTargets and therapy
,PubMed ID 28356756
|
Simvastatin-induced sphingosine 1−phosphate receptor 1 expression is KLF2-dependent in human lung endothelial cells
,null,
Pulmonary Circulation
,PubMed ID 28680571
|
Molecular Mechanisms of Allosteric Inhibition of Brain Glycogen Phosphorylase by Neurotoxic Dithiocarbamate Chemicals *
,null,
The Journal of Biological Chemistry
,PubMed ID 27965358
|
Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells protected by the microenvironment
,null,
Oncotarget
,PubMed ID 28088788
|
Aurora B expression modulates paclitaxel response in non-small cell lung cancer
,null,
British Journal of Cancer
,PubMed ID 28095398
|
Clinically Distinct Phenotypes of Canavan Disease Correlate with Residual Aspartoacylase Enzyme Activity
,null,
Human Mutation
,PubMed ID 28101991
|
NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia
,null,
PLoS ONE
,PubMed ID 28151996
|
The mitotic checkpoint regulator RAE1 induces aggressive breast cancer cell phenotypes by mediating epithelial-mesenchymal transition
,null,
Scientific Reports
,PubMed ID 28181567
|
Hyaluronic acid synthesis is required for zebrafish tail fin regeneration
,null,
PLoS ONE
,PubMed ID 28207787
|
Ectopic expression of meiotic cohesin RAD21L promotes adjacency of homologous chromosomes in somatic cells
,null,
The Journal of Reproduction and Development
,PubMed ID 28239026
|
MicroRNA-320 inhibits invasion and induces apoptosis by targeting CRKL and inhibiting ERK and AKT signaling in gastric cancer cells
,null,
OncoTargets and therapy
,PubMed ID 28255248
|
Reduced Klotho expression contributes to poor survival rates in human patients with ovarian cancer, and overexpression of Klotho inhibits the progression of ovarian cancer partly via the inhibition of systemic inflammation in nude mice.
,null,
Molecular medicine reports
,PubMed ID 28259911
|
Tbx2 confers poor prognosis in glioblastoma and promotes temozolomide resistance with change of mitochondrial dynamics
,null,
OncoTargets and therapy
,PubMed ID 28260920
|
Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells
,null,
Cell Cycle
,PubMed ID 28278050
|
The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal‐to‐zygotic transition
,null,
EMBO Reports
,PubMed ID 28073917
|
The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel
,null,
Frontiers in Molecular Neuroscience
,PubMed ID 28197074
|
Novel Candidate Genes and a Wide Spectrum of Structural and Point Mutations Responsible for Inherited Retinal Dystrophies Revealed by Exome Sequencing
,null,
PLoS ONE
,PubMed ID 28005958
|
Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion.
,null,
Journal of cellular physiology
,PubMed ID 27736039
|
Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane *
,null,
The Journal of Biological Chemistry
,PubMed ID 27770022
|
Deregulation of RUNX2 by miR-320a deficiency impairs steroidogenesis in cumulus granulosa cells from polycystic ovary syndrome (PCOS) patients.
,null,
Biochemical and biophysical research communications
,PubMed ID 27965096
|
The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme
,null,
Scientific Reports
,PubMed ID 27974822
|
HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma
,null,
EMBO Reports
,PubMed ID 28028031
|
Aldehyde dehydrogenase activity plays no functional role in stem cell-like properties in anaplastic thyroid cancer cell lines.
,null,
Endocrine
,PubMed ID 28040834
|
Gamma-interferon-inducible, lysosome/endosome-localized thiolreductase, GILT, has anti-retroviral activity and its expression is counteracted by HIV-1
,Kubo, Y;Izumida, M;Yashima, Y;Yoshii-Kamiyama, H;Tanaka, Y;Yasui, K;Hayashi, H;Matsuyama, T;,
Oncotarget
,PubMed ID 27655726
[PCMV6-XL4]
|
Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia/Reperfusion Injury via Increased Linkage with Gα12
,null,
Transplantation
,PubMed ID 25989500
|
Clinical and Genetic Features of Patients With TNFRSF1A Variants in Japan: Findings of a Nationwide Survey.
,null,
Arthritis rheumatology (Hoboken, N.J.)
,PubMed ID 27332769
|
SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer
,null,
Oncotarget
,PubMed ID 27637080
|
The long chain α-tocopherol metabolite α-13'-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180.
,null,
Molecular nutrition food research
,PubMed ID 27714977
|
Redox-dependent regulation of hepatocyte AIM2 inflammasome activation in sterile liver injury in mice
,null,
Hepatology (Baltimore, Md.)
,PubMed ID 27774630
|
Peroxisomal protein PEX13 functions in selective autophagy
,null,
EMBO Reports
,PubMed ID 27827795
|
Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
,null,
Cell Death & Disease
,PubMed ID 27831555
|
Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1
,null,
Scientific Reports
,PubMed ID 27853315
|
Intracellular cysteine oxidation is modulated by aquaporin-8-mediated hydrogen peroxide channeling in leukaemia cells.
,null,
BioFactors (Oxford, England)
,PubMed ID 27862460
|
Clementine juice has the potential for drug interactions - In vitro comparison with grapefruit and mandarin juice.
,null,
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
,PubMed ID 27890698
|
Evaluation of recombinant monoclonal antibody SVmab1 binding to NaV1.7 target sequences and block of human NaV1.7 currents
,null,
F1000Research
,PubMed ID 27990272
|
CRKL overexpression promotes cell proliferation and inhibits apoptosis in endometrial carcinoma
,null,
Oncology Letters
,PubMed ID 28123521
|
Dysregulated expression of arginine metabolic enzymes in human intestinal tissues of necrotizing enterocolitis and response of CaCO2 cells to bacterial components.
,null,
The Journal of nutritional biochemistry
,PubMed ID 26895666
|
Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer
,null,
Oncotarget
,PubMed ID 27650548
|
Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL
,null,
Oncotarget
,PubMed ID 27626698
|
Impact of R264C and R264H polymorphisms in human aromatase function.
,null,
The Journal of steroid biochemistry and molecular biology
,PubMed ID 27702664
|
A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis
,null,
Arthritis Research & Therapy
,PubMed ID 27716427
|
HCRP1 is downregulated in non-small cell lung cancer and regulates proliferation, invasion, and drug resistance.
,null,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
,PubMed ID 27739029
|
PBX3 promotes gastric cancer invasion and metastasis by inducing epithelial-mesenchymal transition
,null,
Oncology Letters
,PubMed ID 27900025
|
A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity
,null,
Human Molecular Genetics
,PubMed ID 27466201
|
An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome
,null,
Human Molecular Genetics
,PubMed ID 27466187
|
Effect of sildenafil on human aromatase activity: From in vitro structural analysis to catalysis and inhibition in cells.
,null,
The Journal of steroid biochemistry and molecular biology
,PubMed ID 27616271
|
Role of OATP Transporters in Steroid Uptake by Prostate Cancer Cells in Vivo
,null,
Prostate cancer and prostatic diseases
,PubMed ID 27645128
|
Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome
,null,
Nature Communications
,PubMed ID 27653213
|
Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A.
,null,
Endocrinology
,PubMed ID 27673554
|
Crk-like adapter protein is overexpressed in cervical carcinoma, facilitates proliferation, invasion and chemoresistance, and regulates Src and Akt signaling
,null,
Oncology Letters
,PubMed ID 27895735
|
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain
,Proudfoot, CJ;Garry, EM;Cottrell, DF;Rosie, R;Anderson, H;Robertson, DC;Walker, SM;Mitchell, R;,
Current biology
,PubMed ID 16920620
|
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
,null,
Oncogene
,PubMed ID 24909168
|
Induction of Lumen Formation in a Three-dimensional Model of Mammary Morphogenesis by Transcriptional Regulator ID4
,null,
The Journal of Biological Chemistry
,PubMed ID 27302061
|
miRNA-342 Regulates CEACAM1-induced Lumen Formation in a Three-dimensional Model of Mammary Gland Morphogenesis *
,null,
The Journal of Biological Chemistry
,PubMed ID 27302063
|
TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype
,null,
Oncotarget
,PubMed ID 27418133
|
CCSP G38A polymorphism environment interactions regulate CCSP levels differentially in COPD.
,null,
American journal of physiology. Lung cellular and molecular physiology
,PubMed ID 27496897
|
Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes
,null,
Arthritis Research & Therapy
,PubMed ID 27515912
|
Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion.
,null,
Virchows Archiv : an international journal of pathology
,PubMed ID 27553355
|
The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4
,null,
Biochemical pharmacology
,PubMed ID 27569425
|
Mediation of the malignant biological characteristics of gastric cancer cells by the methylated CpG islands in RNF180 DNA promoter
,null,
Oncotarget
,PubMed ID 27223257
|
Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes
,null,
Human Molecular Genetics
,PubMed ID 27126638
|
Mitochondrial Peroxiredoxin-3 protects against hyperglycemia induced myocardial damage in Diabetic cardiomyopathy.
,null,
Free radical biology medicine
,PubMed ID 27393003
|
Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice
,null,
Epigenetics & Chromatin
,PubMed ID 27413395
|
BARHL2 Methylation Using Gastric Wash DNA or Gastric Juice Exosomal DNA is a Useful Marker For Early Detection of Gastric Cancer in an H.pylori-Independent Manner
,null,
Clinical and Translational Gastroenterology
,PubMed ID 27441821
|
A Point Mutation in DNA Polymerase β (POLB) Gene Is Associated with Increased Progesterone Receptor (PR) Expression and Intraperitoneal Metastasis in Gastric Cancer
,null,
Journal of Cancer
,PubMed ID 27471563
|
APPL1 promotes glucose uptake in response to mechanical stretch via the PKCζ-non-muscle myosin IIa pathway in C2C12 myotubes.
,null,
Cellular signalling
,PubMed ID 27478065
|
Application of MS Transport Assays to the Four Human γ-Aminobutyric Acid Transporters.
,null,
ChemMedChem
,PubMed ID 26220444
|
Scaffold-mediated BMP-2 minicircle DNA delivery accelerated bone repair in a mouse critical-size calvarial defect model
,null,
Journal of biomedical materials research. Part A
,PubMed ID 27059085
|
Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish
,null,
Oncotarget
,PubMed ID 27166257
|
DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins
,null,
The EMBO Journal
,PubMed ID 27261198
|
Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment
,null,
PLoS Pathogens
,PubMed ID 27281338
|
Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation
,null,
Oncotarget
,PubMed ID 27284014
|
SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis
,null,
Cell Reports
,PubMed ID 27292644
|
Coiled-coil domain-containing protein 8 inhibits the invasiveness and migration of non-small cell lung cancer cells.
,null,
Human pathology
,PubMed ID 27342910
|
N-terminal tetrapeptide T/SPLH motifs contribute to multimodal activation of human TRPA1 channel
,null,
Scientific Reports
,PubMed ID 27345869
|
Molecular and proteomic insight into Notch1 characterization in hepatocellular carcinoma
,Giovannini, C;Minguzzi, M;Genovese, F;Baglioni, M;Gualandi, A;Ravaioli, M;Milazzo, M;Tavolari, S;Bolondi, L;Gramantieri, L;,
Oncotarget
,PubMed ID 27167202
[PCMV6-XL4]
|
Tools to discriminate between targets of CK2 vs PLK2/PLK3 acidophilic kinases.
,null,
BioTechniques
,PubMed ID 26307252
|
Transient overexpression of exogenous APOBEC3A causes C-to-U RNA editing of thousands of genes
,null,
RNA Biology
,PubMed ID 27149507
|
Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.
,null,
Journal of Alzheimer's disease : JAD
,PubMed ID 27163814
|
TGF-β Signaling Regulates Cementum Formation through Osterix Expression
,null,
Scientific Reports
,PubMed ID 27180803
|
BPTF transduces MITF-driven prosurvival signals in melanoma cells
,null,
Proceedings of the National Academy of Sciences of the United States of America
,PubMed ID 27185926
|
Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis
,null,
The Journal of Investigative Dermatology
,PubMed ID 26778290
|
Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation *
,null,
The Journal of Biological Chemistry
,PubMed ID 26945068
|
Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor.
,null,
The Journal of steroid biochemistry and molecular biology
,PubMed ID 27041117
|
Inhibition of Phosphatase Activity Follows Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor MITF
,null,
PLoS ONE
,PubMed ID 27078017
|
Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions
,null,
PLoS ONE
,PubMed ID 27100999
|
Loss of C9 ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
,null,
The EMBO Journal
,PubMed ID 27103069
|
The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis
,null,
American Journal of Physiology - Lung Cellular and Molecular Physiology
,PubMed ID 27106291
|
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis
,null,
Neoplasia (New York, N.Y.)
,PubMed ID 27108387
|
Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells.
,null,
Free radical biology medicine
,PubMed ID 27130033
|
HOXC9 Induces Phenotypic Switching between Proliferation and Invasion in Breast Cancer Cells
,null,
Journal of Cancer
,PubMed ID 27162534
|
TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians
,null,
Cardiovascular Research
,PubMed ID 26762269
|
AP-1 Is a Key Regulator of Proinflammatory Cytokine TNFα-mediated Triple-negative Breast Cancer Progression *
,null,
The Journal of Biological Chemistry
,PubMed ID 26792858
|
Aquaporin-3 Controls Breast Cancer Cell Migration by Regulating Hydrogen Peroxide Transport and Its Downstream Cell Signaling
,null,
Molecular and Cellular Biology
,PubMed ID 26830227
|
Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment
,null,
PLoS ONE
,PubMed ID 26960140
|
Oxysterol-Related-Binding-Protein Related Protein-2 (ORP2) Regulates Cortisol Biosynthesis and Cholesterol Homeostasis
,null,
Molecular and cellular endocrinology
,PubMed ID 26992564
|
MAP4K4 promotes epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma.
,null,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
,PubMed ID 27010469
|
PKCε inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P.
,null,
Cancer letters
,PubMed ID 27037060
|
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
,null,
Hepatology (Baltimore, Md.)
,PubMed ID 26698170
|
Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling *
,null,
The Journal of Biological Chemistry
,PubMed ID 26719333
|
Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions
,null,
Molecular pharmaceutics
,PubMed ID 26750564
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Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia Coli
,null,
Protein expression and purification
,PubMed ID 26923061
|
Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line
,null,
Biological Research
,PubMed ID 26796959
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Junctional adhesion molecule-A is overexpressed in advanced multiple myeloma and determines response to oncolytic reovirus
,null,
Oncotarget
,PubMed ID 26513296
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Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)
,null,
Molecular pharmaceutics
,PubMed ID 26528626
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Potential involvement of placental Ahr in unexplained recurrent spontaneous abortion
,Wu, Y;Chen, X;Chang, X;Huang, YJ;Bao, S;He, Q;Li, Y;Zheng, J;Duan, T;Wang, K;,
Reprod. Toxicol.
,PubMed ID 26593447
[PCMV6XL4]
|
Suppression of agrin-22 production and synaptic dysfunction in Cln1-/- mice
,Peng, S;Xu, J;Pelkey, KA;Chandra, G;,
Annals of Clinical and Translational Neurology
,PubMed ID 26734660
[PCMV6XL4]
|
Hamster SRD5A3 lacks steroid 5α-reductase activity in vitro.
,null,
Steroids
,PubMed ID 25498908
|
HER2 missense mutations have distinct effects on oncogenic signaling and migration
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Proceedings of the National Academy of Sciences of the United States of America
,PubMed ID 26508629
|
Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress
,null,
Carcinogenesis
,PubMed ID 26542370
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Testicular acid phosphatase induces odontoblast differentiation and mineralization.
,null,
Cell and tissue research
,PubMed ID 26547858
|
Autophagy positively regulates DNA damage recognition by nucleotide excision repair
,null,
Autophagy
,PubMed ID 26565512
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Loss of GATA5 expression due to gene promoter methylation induces growth and colony formation of hepatocellular carcinoma cells
,null,
Oncology Letters
,PubMed ID 26870297
|
Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy
,Ishikawa, K;He, S;Terasaki, H;Nazari, H;Zhang, H;Spee, C;Kannan, R;Hinton, DR;,
Sci Rep
,PubMed ID 26552368
[PCMV6XL4]
|
Dysregulated expression of arginine metabolic enzymes in human intestinal tissues of necrotizing enterocolitis and response of CaCO2 cells to bacterial components
,Leung, KT;Chan, KYY;Ma, TPY;Yu, JWS;,
The Journal of Nutritional Biochemistry
[PCMV6XL4]
|
Targeting FAK scaffold functions inhibits human renal cell carcinoma growth.
,null,
International journal of cancer
,PubMed ID 25809490
|
hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway
,null,
Nucleic Acids Research
,PubMed ID 26261212
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Pinosylvin Inhibits TRPA1-Induced Calcium Influx In Vitro and TRPA1-Mediated Acute Paw Inflammation In Vivo.
,null,
Basic clinical pharmacology toxicology
,PubMed ID 26335783
|
The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits
,null,
PLoS Neglected Tropical Diseases
,PubMed ID 26437177
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JRK is a positive regulator of β-catenin transcriptional activity commonly overexpressed in colon, breast and ovarian cancer
,null,
Oncogene
,PubMed ID 26455321
|
Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain
,null,
Scientific Reports
,PubMed ID 26477568
|
Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex
,null,
Emerging Microbes & Infections
,PubMed ID 26576339
|
Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity
,null,
Journal of Lipid Research
,PubMed ID 27230263
|
Therapeutic impact of systemic AAV-mediated RNA interference in a mouse model of myotonic dystrophy
,null,
Human Molecular Genetics
,PubMed ID 26082468
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Human stem cells from the apical papilla response to bacterial lipopolysaccharide exposure and anti-inflammatory effects of nuclear factor I C.
,null,
Journal of endodontics
,PubMed ID 24139265
|
Prediction and validation of enzyme and transporter off-targets for metformin
,null,
Journal of pharmacokinetics and pharmacodynamics
,PubMed ID 26335661
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Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling
,null,
BMC Cancer
,PubMed ID 26373535
|
The effects of RelB deficiency on lymphocyte development and function.
,null,
Journal of autoimmunity
,PubMed ID 26385063
|
Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons
,null,
Molecular Pain
,PubMed ID 26408173
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Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness *Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness * ♦
,null,
The Journal of Biological Chemistry
,PubMed ID 25998128
|
Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines.
,null,
The Journal of pharmacy and pharmacology
,PubMed ID 26255619
|
p75NTR-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte–endothelial crosstalk in diabetes after limb ischaemia
,null,
Nature Communications
,PubMed ID 26268439
|
Downregulated ECRG4 is associated with poor prognosis in renal cell cancer and is regulated by promoter DNA methylation.
,null,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
,PubMed ID 26276361
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Overexpression of SPAG9 in human gastric cancer is correlated with poor prognosis.
,null,
Virchows Archiv : an international journal of pathology
,PubMed ID 26293216
|
Upregulation and Mitochondrial Sequestration of Hemoglobin Occur in Circulating Leukocytes during Critical Illness, Conferring a Cytoprotective Phenotype
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Molecular Medicine
,PubMed ID 26322851
|
Sox9 expression in carcinogenesis and its clinical significance in intrahepatic cholangiocarcinoma.
,null,
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
,PubMed ID 26341967
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3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease
,Lau, AJ;Chang, TK;,
Pharmacol. Res.
,PubMed ID 26238175
[PCMV6XL4]
|
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics
,null,
Human Molecular Genetics
,PubMed ID 25882706
|
Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay *
,null,
The Journal of Biological Chemistry
,PubMed ID 25995455
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Plasmodium falciparum adhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor
,null,
Cellular microbiology
,PubMed ID 26118955
|
Andrographolide inhibits the migration, invasion and matrix metalloproteinase expression of rheumatoid arthritis fibroblast-like synoviocytes via inhibition of HIF-1α signaling.
,null,
Life sciences
,PubMed ID 26141990
|
KRASG12D-mediated oncogenic transformation of thyroid follicular cells requires long-term TSH stimulation and is regulated by SPRY1
,null,
Laboratory investigation; a journal of technical methods and pathology
,PubMed ID 26146959
|
Induction of Resistance to BRAF Inhibitor Is Associated with the Inability of Spry2 to Inhibit BRAF-V600E Activity in BRAF Mutant Cells
,null,
Biomolecules & Therapeutics
,PubMed ID 26157547
|
Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis
,null,
Breast Cancer Research : BCR
,PubMed ID 26208975
|
IL-1α Gene Deletion Protects Oligodendrocytes after Spinal Cord Injury through Upregulation of the Survival Factor Tox3
,null,
The Journal of Neuroscience
,PubMed ID 26224856
|
Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN
,null,
Oncotarget
,PubMed ID 25883222
|
The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception
,null,
Cell Cycle
,PubMed ID 25891934
|
Posttranslational removal of α-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women.
,null,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
,PubMed ID 26077903
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Zoledronic acid inhibits the pentose phosphate pathway through attenuating the Ras-TAp73-G6PD axis in bladder cancer cells.
,null,
Molecular medicine reports
,PubMed ID 26126921
|
DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma
,null,
The Journal of Experimental Medicine
,PubMed ID 25847947
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Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement *
,null,
The Journal of Biological Chemistry
,PubMed ID 25864199
|
Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer
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PLoS ONE
,PubMed ID 25954972
|
Na+/Taurocholate Cotransporting Polypeptide and Apical Sodium-Dependent Bile Acid Transporter Are Involved in the Disposition of Perfluoroalkyl Sulfonates in Humans and Rats
,null,
Toxicological Sciences
,PubMed ID 26001962
|
Sar1b transgenic male mice are more susceptible to high-fat diet-induced obesity, insulin insensitivity and intestinal chylomicron overproduction.
,null,
The Journal of nutritional biochemistry
,PubMed ID 24657056
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Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity [S]
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Journal of Lipid Research
,PubMed ID 26175473
|
Chondroitin Sulfate Accelerates Trans-Golgi-to-Surface Transport of Proteoglycan Amyloid Precursor Protein
,Mihov, D;Raja, E;Spiess, M;,
Traffic
,PubMed ID 25951880
[PCMV6XL4]
|
Biased Agonism as a Novel Strategy To Harness the Proresolving Properties of Melanocortin Receptors without Eliciting Melanogenic Effects
,Montero-Melendez, T;Gobbetti, T;Cooray, SN;Jonassen, TE;Perretti, M;,
J. Immunol.
,PubMed ID 25725103
[PCMV6XL4]
|
Action of Obestatin in Skeletal Muscle Repair: Stem Cell Expansion, Muscle Growth, and Microenvironment Remodeling
,null,
Molecular Therapy
,PubMed ID 25762009
|
TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis
,null,
Oncotarget
,PubMed ID 25762644
|
Mutant p53 expression in fallopian tube epithelium drives cell migration
,null,
International journal of cancer. Journal international du cancer
,PubMed ID 25810107
|
APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages
,null,
Nature Communications
,PubMed ID 25898173
|
Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling
,null,
BioMed Research International
,PubMed ID 25961039
|
EGR-1/Bax Pathway Plays a Role in Vitamin E δ-Tocotrienol-induced Apoptosis in Pancreatic Cancer Cells
,null,
The Journal of nutritional biochemistry
,PubMed ID 25997867
|
Synergistic Induction of Erlotinib-Mediated Apoptosis by Resveratrol in Human Non-Small-Cell Lung Cancer Cells by Down-Regulating Survivin and Up-Regulating PUMA
,Nie, P;Hu, W;Zhang, T;Yang, Y;Hou, B;Zou, Z;,
Cell. Physiol. Biochem.
,PubMed ID 25895606
[PCMV6XL4]
|
Aberrant Liver Insulin Receptor Isoform A Expression Normalises with Remission of Type 2 Diabetes after Gastric Bypass Surgery
,null,
PLoS ONE
,PubMed ID 25742416
|
Production of Functional Human Vitamin A Transporter/RBP Receptor (STRA6) for Structure Determination
,null,
PLoS ONE
,PubMed ID 25816144
|
Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma
,null,
Drug Design, Development and Therapy
,PubMed ID 25848214
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Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant
,null,
EBioMedicine
,PubMed ID 26086037
|
UBE2L3 Polymorphism Amplifies NF-κB Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases
,null,
American Journal of Human Genetics
,PubMed ID 25640675
|
Urate Crystal Induced Inflammation and Joint Pain Are Reduced in Transient Receptor Potential Ankyrin 1 Deficient Mice – Potential Role for Transient Receptor Potential Ankyrin 1 in Gout
,null,
PLoS ONE
,PubMed ID 25658427
|
Nuclear Factor I-C promotes proliferation and differentiation of apical papilla-derived human stem cells in vitro.
,null,
Experimental cell research
,PubMed ID 25668322
|
Safety and angiogenic effects of systemic gene delivery of a modified erythropoietin
,null,
Gene therapy
,PubMed ID 25716531
|
Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state.
,null,
Neuropharmacology
,PubMed ID 25724085
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Epithelial calcium-sensing receptor activation by eosinophil granule protein analog stimulates collagen matrix contraction
,null,
Pediatric research
,PubMed ID 23269116
|
Suppression of endothelial nitric oxide synthase expression and endothelial cell proliferation by an intronic 27-ntmiRNA and it’s a novel link to AP-1
,null,
American Journal of Translational Research
,PubMed ID 25901197
|
A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury
,Wei, Z;Yu, D;Bi, Y;Cao, Y;,
Mol Med Rep
,PubMed ID 25738567
[PCMV6XL4]
|
Polyamine Metabolism is Sensitive to Glycolysis Inhibition in Human Neuroblastoma Cells
,Ruiz-Pérez, MV;Medina, MÁ;Urdiales, JL;Keinänen, TA;Sánchez-Jiménez, F;,
J. Biol. Chem.
,PubMed ID 25593318
[PCMV6XL4]
|
CD44 regulates pancreatic cancer invasion through MT1-MMP
,null,
Molecular cancer research : MCR
,PubMed ID 25566991
|
Variable Expression of PIK3R3 and PTEN in Ewing Sarcoma Impacts Oncogenic Phenotypes
,null,
PLoS ONE
,PubMed ID 25603314
|
ADAM8 as a drug target in Pancreatic Cancer
,null,
Nature communications
,PubMed ID 25629724
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ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis
,null,
Journal of Lipid Research
,PubMed ID 25691431
|
Basic Motifs Target PSGL-1, CD43, and CD44 to Plasma Membrane Sites Where HIV-1 Assembles
,null,
Journal of Virology
,PubMed ID 25320329
|
FOXO3a modulates WNT/ß-catenin signaling and suppresses epithelial-to-mesenchymal transition in prostate cancer cells
,Liu, H;Yin, J;Wang, H;Jiang, G;Deng, M;Zhang, G;Bu, X;Cai, S;Du, J;He, Z;,
Cell. Signal.
,PubMed ID 25578861
[PCMV6XL4]
|
Molecular Pharmacology and Ligand Docking Studies Reveal a Single Amino Acid Difference between Mouse and Human Serotonin 5-HT2A Receptors That Impacts Behavioral Translation of Novel 4-Phenyl-2-dimethylaminotetralin Ligands
,null,
The Journal of Pharmacology and Experimental Therapeutics
,PubMed ID 24080681
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Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells
,Zhang, L;Dai, F;Cui, L;Jing, H;Fan, P;Tan, X;Guo, Y;Zhou, G;,
Biochim. Biophys. Acta
,PubMed ID 25476892
[PCMV6XL4]
|
Claudin-4 is required for AMPK-modulated paracellular permeability in submandibular gland cells.
,null,
Journal of molecular cell biology
,PubMed ID 25503106
|
The immunoregulator soluble TACI is released by ADAM10 and reflects B-cell activation in autoimmunity
,null,
Journal of immunology (Baltimore, Md. : 1950)
,PubMed ID 25505277
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PROX1 Gene is Differentially Expressed in Oral Cancer and Reduces Cellular Proliferation
,null,
Medicine
,PubMed ID 25526434
|
Ability of naringenin, a bioflavonoid, to activate M-type potassium current in motor neuron-like cells and to increase BKCa-channel activity in HEK293T cells transfected with α-hSlo subunit
,null,
BMC Neuroscience
,PubMed ID 25539574
|
Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells
,null,
Oncotarget
,PubMed ID 25544768
|
Intestinal neuroendocrine cells and goblet cells are mediators of IL-17A-amplified epithelial IL-17C production in human inflammatory bowel disease
,Friedrich, M;Diegelmann, J;Schauber, J;Auernhammer, CJ;Brand, S;,
Mucosal Immunol
,PubMed ID 25492478
[PCMV6XL4]
|
Characterization and expression of proprotein convertases in CHO cells: Efficient proteolytic maturation of human bone morphogenetic protein-7.
,null,
Biotechnology and bioengineering
,PubMed ID 25219685
|
Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome
,null,
Blood
,PubMed ID 25253772
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The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines
,null,
The EMBO Journal
,PubMed ID 25260751
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Computational and Functional Characterization of Angiogenin Mutations, and Correlation with Amyotrophic Lateral Sclerosis
,null,
PLoS ONE
,PubMed ID 25372031
|
Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes
,null,
Nature genetics
,PubMed ID 25401301
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Reduced Expression of PTPRD Correlates with Poor Prognosis in Gastric Adenocarcinoma
,null,
PLoS ONE
,PubMed ID 25412184
|
Nucleofection optimization and in vitro anti-tumourigenic effect of TRAIL-expressing human adipose-derived mesenchymal stromal cells
,null,
Cancer Cell International
,PubMed ID 25469108
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DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling
,null,
American Journal of Cancer Research
,PubMed ID 25520862
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The Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension
,null,
American Journal of Respiratory and Critical Care Medicine
,PubMed ID 25180446
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C/EBP Transcription Factors in Human Squamous Cell Carcinoma: Selective Changes in Expression of Isoforms Correlate with the Neoplastic State
,null,
PLoS ONE
,PubMed ID 25402211
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Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine
,Sharma, D;Lau, AJ;Sherman, MA;Chang, TK;,
Br. J. Pharmacol.
,PubMed ID 25363652
[Transfection]
|
Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice
,Al-Dwairi, A;Brown, AR;Pabona, JM;Van, TH;Hamdan, H;Mercado, CP;Quick, CM;Wight, PA;Simmen, RC;Simmen, FA;,
PLoS ONE
,PubMed ID 25402228
[Others]
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Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families
,null,
Human Molecular Genetics
,PubMed ID 24879641
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Dystroglycan Binding to α-Neurexin Competes with Neurexophilin-1 and Neuroligin in the Brain *
,null,
The Journal of Biological Chemistry
,PubMed ID 25157101
|
Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells
,null,
BMC Cancer
,PubMed ID 25323222
|
Investigation of hFVIII Production in Mammary Glands of Transgenic Mice
,null,
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
,PubMed ID 25358000
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Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance
,null,
Oncotarget
,PubMed ID 25426549
|
Cortactin autoantibodies in myasthenia gravis.
,null,
Autoimmunity reviews
,PubMed ID 25193850
|
Silencing of CDC42 inhibits neuroblastoma cell proliferation and transformation
,null,
Cancer letters
,PubMed ID 25264923
|
Ubiquitin-specific Peptidase 20 Regulates Rad17 Stability, Checkpoint Kinase 1 Phosphorylation and DNA Repair by Homologous Recombination *
,null,
The Journal of Biological Chemistry
,PubMed ID 24923443
|
LPS Induces the Degradation of Programmed Cell Death Protein 4 (PDCD4) to Release Twist2, Activating c-Maf Transcription to Promote Interleukin-10 Production *
,null,
The Journal of Biological Chemistry
,PubMed ID 24982420
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Transactivation of the Receptor-tyrosine Kinase Ephrin Receptor A2 Is Required for the Low Molecular Weight Hyaluronan-mediated Angiogenesis That Is implicated in Tumor Progression *
,null,
The Journal of Biological Chemistry
,PubMed ID 25023279
|
Prediction of miRNA-mRNA associations in Alzheimer’s disease mice using network topology
,null,
BMC Genomics
,PubMed ID 25086961
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A Heroin Addiction Severity-Associated Intronic Single Nucleotide Polymorphism Modulates Alternative Pre-mRNA Splicing of the μ Opioid Receptor Gene OPRM1 via hnRNPH Interactions
,null,
The Journal of Neuroscience
,PubMed ID 25122903
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Epigenetic Inactivation of Inositol polyphosphate 4-phosphatase B (INPP4B), a Regulator of PI3K/AKT Signaling Pathway in EBV-Associated Nasopharyngeal Carcinoma
,null,
PLoS ONE
,PubMed ID 25126743
|
The inhibitor of kappa B kinase-epsilon regulates MMP-3 expression levels and can promote lung metastasis
,null,
Oncogenesis
,PubMed ID 25133483
|
Restoring multidrug resistance-associated protein 3 attenuates cell proliferation in the polycystic kidney.
,null,
American journal of physiology. Renal physiology
,PubMed ID 25143454
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HNF4α induced chemosensitivity to oxaliplatin and 5-FU mediated by OCT1 and CNT3 in renal cell carcinoma.
,null,
Journal of pharmaceutical sciences
,PubMed ID 25175346
|
Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.
,null,
Molecular neurobiology
,PubMed ID 24990319
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Identification of Functional Amino Acid Residues Involved in Polyamine and Agmatine Transport by Human Organic Cation Transporter 2
,null,
PLoS ONE
,PubMed ID 25019617
|
Boronate-Based Fluorescent Probes: Imaging Hydrogen Peroxide in Living Systems
,null,
Methods in enzymology
,PubMed ID 23791092
|
Essential role of aldehyde dehydrogenase 1A3 (ALDH1A3) for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway
,null,
Clinical cancer research : an official journal of the American Association for Cancer Research
,PubMed ID 24907115
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Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14.
,null,
Neurobiology of disease
,PubMed ID 24937631
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Glycerol-3-Phosphate Acyltranferase-2 Behaves as a Cancer Testis Gene and Promotes Growth and Tumorigenicity of the Breast Cancer MDA-MB-231 Cell Line
,null,
PLoS ONE
,PubMed ID 24967918
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Tissue distribution and regulation of the small Sar1b GTPase in mice.
,null,
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
,PubMed ID 24969168
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Activation of Neurotensin Receptor 1 Facilitates Neuronal Excitability and Spatial Learning and Memory in the Entorhinal Cortex: Beneficial Actions in an Alzheimer's Disease Model
,null,
The Journal of Neuroscience
,PubMed ID 24828655
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A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol
,null,
Journal of Lipid Research
,PubMed ID 24958911
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Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype
,null,
Proceedings of the National Academy of Sciences of the United States of America
,PubMed ID 24706793
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Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system.
,null,
Toxicology and applied pharmacology
,PubMed ID 24721719
|
Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi.
,null,
Molecular pharmacology
,PubMed ID 24723491
|
Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells
,null,
American Journal of Physiology - Gastrointestinal and Liver Physiology
,PubMed ID 24763554
|
Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients.
,null,
Leukemia
,PubMed ID 23884370
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The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cells.
,null,
Science signaling
,PubMed ID 24023254
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Imbalance of Hsp70 family variants fosters tau accumulation
,null,
The FASEB Journal
,PubMed ID 23271055
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Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation
,null,
Proceedings of the National Academy of Sciences of the United States of America
,PubMed ID 24616504
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LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition
,null,
Disease Models & Mechanisms
,PubMed ID 24626991
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Peroxisome proliferator-activated receptor γ-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer.
,null,
Biochimica et biophysica acta
,PubMed ID 24631504
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Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in vitro.
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Pulmonary pharmacology therapeutics
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Survivin transcript variant 2 drives angiogenesis and malignant progression in proneural gliomas
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Neuro-Oncology
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Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth.
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Cancer letters
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46,XY disorder of sexual development resulting from a novel monoallelic mutation (p.Ser31Phe) in the steroid 5α-reductase type-2 (SRD5A2) gene
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Molecular Genetics & Genomic Medicine
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Downstream targets of the homeobox gene DLX3 are differentially expressed in the placentae of pregnancies affected by human idiopathic fetal growth restriction.
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Molecular and cellular endocrinology
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FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter
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Journal of Lipid Research
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The helicase HAGE prevents interferon-α-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1
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Cell Death & Disease
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The Expression and Characterization of Functionally Active Soluble CD83 by Pichia pastoris Using High-Density Fermentation
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PLoS ONE
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Endogenous Siderophore 2,5-Dihydroxybenzoic Acid Deficiency Promotes Anemia and Splenic Iron Overload in Mice
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Molecular and Cellular Biology
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Tumor Necrosis Factor and Transforming Growth Factor β Regulate Clock Genes by Controlling the Expression of the Cold Inducible RNA-binding Protein (CIRBP) *
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The Journal of Biological Chemistry
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Specific aquaporins facilitate Nox-produced hydrogen peroxide transport through plasma membrane in leukaemia cells.
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Biochimica et biophysica acta
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Beyond radio-displacement techniques for Identification of CB1 Ligands: The First Application of a Fluorescence-quenching Assay
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Scientific Reports
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Anti-CD79 Antibody Induces B cell Anergy That Protects Against Autoimmunity
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Journal of immunology (Baltimore, Md. : 1950)
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Distinct interaction of nilotinib and imatinib with P-Glycoprotein in intracellular accumulation and cytotoxicity in CML Cell Line K562 cells.
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Biological pharmaceutical bulletin
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TGF-β1 signaling plays a dominant role in the crosstalk between TGF-β1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells.
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Cellular signalling
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HACE1 Is a Tumor Suppressor Gene Candidate in Natural Killer Cell Neoplasms
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The American Journal of Pathology
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A Genome-Wide Association Study in American Indians Implicates DNER as a Susceptibility Locus for Type 2 Diabetes
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Diabetes
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CXCL13-CXCR5 co-expression regulates epithelial to mesenchymal transition of breast cancer cells during lymph node metastasis.
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Breast cancer research and treatment
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Generation of Human Induced Pluripotent Stem Cells Using Epigenetic Regulators Reveals a Germ Cell-Like Identity in Partially Reprogrammed Colonies
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PLoS ONE
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Bimolecular Fluorescence Complementation; Lighting-Up Tau-Tau Interaction in Living Cells
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PLoS ONE
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Drug Metabolism and Disposition
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SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1
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British Journal of Cancer
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Understanding the Role of Argininosuccinate Lyase Transcript Variants in the Clinical and Biochemical Variability of the Urea Cycle Disorder Argininosuccinic Aciduria *
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The Journal of Biological Chemistry
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HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate NeurodegenerationAn HDAC in the Cytoplasm, not the Nucleus, Plays a Pathogenic Role in Huntington's Disease
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PLoS Biology
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Role of P-glycoprotein in the efflux of raltegravir from human intestinal cells and CD4+ T-cells as an interaction target for anti-HIV agents.
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Biochemical and biophysical research communications
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LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure
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Human Molecular Genetics
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Functional Analysis of HSF4 Mutations Found in Patients With Autosomal Recessive Congenital Cataracts
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Investigative Ophthalmology & Visual Science
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Mutation screen of the SIM1 gene in pediatric patients with early-onset obesity.
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International journal of obesity (2005)
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Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin.
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Biochemical and biophysical research communications
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Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity
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BMC Gastroenterology
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A novel role for FOXO3 in human labor: increased expression in laboring myometrium, and regulation of proinflammatory and prolabor mediators in pregnant human myometrial cells.
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Biology of reproduction
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Impact of salt exposure on N-acetylgalactosamine-4-sulfatase (arylsulfatase B) activity, glycosaminoglycans, kininogen, and bradykinin
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Glycoconjugate journal
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β-Glucosidase 2 (GBA2) Activity and Imino Sugar Pharmacology *
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The Journal of Biological Chemistry
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Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+
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Proceedings of the National Academy of Sciences of the United States of America
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Estrogen receptor-β regulates human tryptophan hydroxylase-2 through an estrogen response element in the 5′ untranslated region
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Journal of neurochemistry
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Serine Protease HTRA1 Antagonizes Transforming Growth Factor-? Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation
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PLoS ONE
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Characterization of TRIM62 as a RING finger E3 ubiquitin ligase and its subcellular localization.
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Biochemical and biophysical research communications
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Investigations on Collectin Liver 1 *
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The Journal of Biological Chemistry
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Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo
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International Journal of Nanomedicine
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The Interaction between Factor H and Von Willebrand Factor
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PLoS ONE
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ABCB1 haplotypes do not influence transport or efficacy of tyrosine kinase inhibitors in vitro
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Pharmacogenomics and Personalized Medicine
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Interaction profile of macitentan, a new non-selective endothelin-1 receptor antagonist, in vitro.
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European journal of pharmacology
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Indirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: analysis with 3-hydroxyflavone and its analogues
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British Journal of Pharmacology
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Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells.
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Biological chemistry
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Agonism of human pregnane X receptor by rilpivirine and etravirine: comparison with first generation non-nucleoside reverse transcriptase inhibitors.
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Biochemical pharmacology
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Genetic Analyses of a Three Generation Family Segregating Hirschsprung Disease and Iris Heterochromia
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PLoS ONE
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Long-term exposure of RN46A cells expressing serotonin transporter (SERT) to a cAMP analog up-regulates SERT activity and is accompanied by neural differentiation of the cells.
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Journal of pharmacological sciences
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MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth.
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Cancer letters
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HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates
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Epigenetics
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Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer
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The Journal of pathology
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Human Fc?RII Cytoplasmic Domains Differentially Influence Antibody-Mediated Dengue Virus Infection
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The Journal of Immunology Author Choice
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Ataxia-Telangiectasia Group D Complementing Gene (ATDC) Promotes Lung Cancer Cell Proliferation by Activating NF-?B Pathway
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PLoS ONE
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Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines
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Virology
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Protein Kinase A and Phosphodiesterase-4D3 Binding to Coding Polymorphisms of Cardiac Muscle Anchoring Protein (mAKAP)
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Journal of molecular biology
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Time-resolved fluorescence resonance energy transfer as a versatile tool in the development of homogeneous cellular kinase assays.
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Assay and drug development technologies
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Binding and Repressive Activities of Apolipoprotein E3 and E4 Isoforms on the Human ApoD Promoter
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Molecular Neurobiology
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MPN patients harbor recurrent truncating mutations in transcription factor NF-E2
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The Journal of Experimental Medicine
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The Drosophila GOLPH3 homolog regulates the biosynthesis of heparan sulfate proteoglycans by modulating the retrograde trafficking of exostosins.
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Development (Cambridge, England)
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Comparison of bidirectional and bicistronic inducible systems for coexpression of connexin genes and fluorescent reporters.
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Analytical biochemistry
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Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity
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The FASEB Journal
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A New Signaling Pathway (JAK-Fes-phospholipase D) That Is Enhanced in Highly Proliferative Breast Cancer Cells *
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The Journal of Biological Chemistry
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Fusicoccin A, a Phytotoxic Carbotricyclic Diterpene Glucoside of Fungal Origin, Reduces Proliferation and Invasion of Glioblastoma Cells by Targeting Multiple Tyrosine Kinases 1
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Translational Oncology
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ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance.
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Clinical cancer research : an official journal of the American Association for Cancer Research
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PTPL1 and PKCδ contribute to proapoptotic signalling in prostate cancer cells
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Cell Death & Disease
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Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau
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Biological psychiatry
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MNADK, a novel liver-enriched mitochondrion-localized NAD kinase
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Biology Open
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Selective agonism of human pregnane X receptor by individual ginkgolides.
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Drug metabolism and disposition: the biological fate of chemicals
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Systemic elevation of PTEN induces a tumor suppressive metabolic state
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Cell
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The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation.
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Journal of cell science
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Inhibitory effect of luteolin on the odorant-induced cAMP level in HEK293 cells expressing the olfactory receptor.
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BioFactors (Oxford, England)
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hERG ion channel pharmacology: cell membrane liposomes in porous-supported lipid bilayers compared with whole-cell patch-clamping.
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European biophysics journal : EBJ
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Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu.
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Science signaling
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Effects of ketamine and its metabolites on ion currents in differentiated hippocampal H19-7 neuronal cells and in HEK293T cells transfected with α-hslo subunit.
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Neurotoxicology
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Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage
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Cell Death and Differentiation
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CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer.
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Cancer research
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The Androgen Metabolite, 5?-Androstane-3?,17?-Diol (3?-Diol), Activates the Oxytocin Promoter Through an Estrogen Receptor-? Pathway
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Endocrinology
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Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin
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Cell Death & Disease
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REST is up-regulated by epidermal growth factor in HeLa cells and inhibits apoptosis by influencing histone H3 acetylation.
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Biochimica et biophysica acta
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Influence of sildenafil and tadalafil on the enzyme- and transporter-inducing effects of bosentan and ambrisentan in LS180 cells.
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Biochemical pharmacology
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Drug Metabolism and Disposition
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Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling
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The Journal of Clinical Investigation
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Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome
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PLoS Biology
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Intracellular localization of the BCL-2 family member BOK and functional implications
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Cell Death and Differentiation
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Identification of a candidate therapeutic autophagy-inducing peptide
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Nature
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Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.
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Journal of immunology (Baltimore, Md. : 1950)
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IL-36?/IL-1F9, an Innate T-bet Target in Myeloid Cells *
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The Journal of Biological Chemistry
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2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation
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Nucleic Acids Research
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CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma.
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The American journal of pathology
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ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity.
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The American journal of pathology
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WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression
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Journal of Cell Science
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Mutation in PNPT1, which Encodes a Polyribonucleotide Nucleotidyltransferase, Impairs RNA Import into Mitochondria and Causes Respiratory-Chain Deficiency
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American Journal of Human Genetics
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Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans
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Development (Cambridge, England)
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Synthesis and Characterization of a Melanoma-Targeted Fluorescence Imaging Probe by Conjugation of a Melanocortin 1 Receptor (MC1R) Specific Ligand
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Bioconjugate chemistry
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Hkat, a novel nutritionally regulated transmembrane protein in adipose tissues
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Scientific Reports
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IGFBP7's susceptibility to proteolysis is altered by A-to-I RNA editing of its transcript.
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FEBS letters
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Comparison of LanthaScreen Eu Kinase Binding Assay and Surface Plasmon Resonance Method in Elucidating the Binding Kinetics of Focal Adhesion Kinase Inhibitors
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ASSAY and Drug Development Technologies
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Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid ? and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production *
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The Journal of Biological Chemistry
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c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway
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Molecules
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Non-Viral Transfection Methods Optimized for Gene Delivery to a Lung Cancer Cell Line
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Avicenna Journal of Medical Biotechnology
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B-cell Translocation Gene 2 (BTG2) Stimulates Cellular Antioxidant Defenses through the Antioxidant Transcription Factor NFE2L2 in Human Mammary Epithelial Cells *
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The Journal of Biological Chemistry
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Frank-ter Haar Syndrome Protein Tks4 Regulates Epidermal Growth Factor-dependent Cell Migration *
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The Journal of Biological Chemistry
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Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation
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PLoS ONE
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Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer
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Breast Cancer Research : BCR
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Nrac, a Novel Nutritionally-Regulated Adipose and Cardiac-Enriched Gene
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PLoS ONE
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Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.
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Drug metabolism and disposition: the biological fate of chemicals
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Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects.
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European journal of clinical pharmacology
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In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2.
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The Journal of pathology
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CD146 Expression in Human Breast Cancer Cell Lines Induces Phenotypic and Functional Changes Observed in Epithelial to Mesenchymal Transition
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PLoS ONE
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Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications
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BMC Cancer
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Mutations in a P-Type ATPase Gene Cause Axonal Degeneration
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PLoS Genetics
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The structure of human tripeptidyl peptidase II as determined by a hybrid approach.
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Structure (London, England : 1993)
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Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation
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Molecular Biology of the Cell
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Transcriptional Activation of Prostate Specific Homeobox Gene NKX3-1 in Subsets of T-Cell Lymphoblastic Leukemia (T-ALL)
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PLoS ONE
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Caspase-14: A novel caspase in the retina with a potential role in diabetic retinopathy
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Molecular Vision
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Biochemical and pharmacological characterization of human ?/?-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12) [S]
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Journal of Lipid Research
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Nonoisotopic Assay for the Presynaptic Choline Transporter Reveals Capacity for Allosteric Modulation of Choline Uptake
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ACS Chemical Neuroscience
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Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors.
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Cancer letters
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Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress
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Cell Death & Disease
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DNAJB6 governs a novel regulatory loop determining Wnt/?-catenin signaling activity
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The Biochemical journal
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Phospholipase C not protein kinase C is required for the activation of TRPC5 channels by cholecystokinin
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European Journal of Pharmacology
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The let-7 microRNA Enhances Heme Oxygenase-1 by Suppressing Bach1 and Attenuates Oxidant Injury in Human Hepatocytes
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Biochimica et biophysica acta
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Hypogonadism in a patient with two novel mutations of the luteinizing hormone β-subunit gene expressed in a compound heterozygous form.
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The Journal of clinical endocrinology and metabolism
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Transcription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms
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Haematologica
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Modulation of chemotactic and pro-inflammatory activities of endothelial progenitor cells by hepatocellular carcinoma.
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Cellular signalling
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Development of Transgenic Cloned Pig Models of Skin Inflammation by DNA Transposon-Directed Ectopic Expression of Human β1 and α2 Integrin
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PLoS ONE
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C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel *
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The Journal of Biological Chemistry
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Extracellular Nucleotides Inhibit Insulin Receptor Signaling, Stimulate Autophagy and Control Lipoprotein Secretion
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PLoS ONE
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Substrate kringle-mediated catalysis by the streptokinase-plasmin activator complex: critical contribution of kringle-4 revealed by the mutagenesis approaches.
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Biochimica et biophysica acta
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TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse
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Scientific Reports
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A Preclinical Assessment of Neural Stem Cells as Delivery Vehicles for Anti-Amyloid Therapeutics
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PLoS ONE
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Recognition of dextran-superparamagnetic iron oxide nanoparticle conjugates (Feridex) via macrophage scavenger receptor charged domains
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Bioconjugate chemistry
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Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms
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Oncogene
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Intronic microRNA suppresses endothelial nitric oxide synthase expression and endothelial cell proliferation via inhibition of STAT3 signaling.
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Molecular and cellular biochemistry
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Full-length human glutaminase in complex with an allosteric inhibitor.
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Biochemistry
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Pure haploinsufficiency for Dravet syndrome Na(V)1.1 (SCN1A) sodium channel truncating mutations.
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Epilepsia
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Mechanism of Platelet Factor 4 (PF4) Deficiency with RUNX1 Haplodeficiency: RUNX1 is a Transcriptional Regulator of PF4
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Journal of thrombosis and haemostasis : JTH
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Cytoplasmic Metadherin (MTDH) Provides Survival Advantage under Conditions of Stress by Acting as RNA-binding Protein
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The Journal of Biological Chemistry
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A Novel Aquaporin 3 in Killifish (Fundulus heteroclitus) Is Not An Arsenic Channel
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Toxicological Sciences
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FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6
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PLoS ONE
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The translational landscape of mTOR signalling steers cancer initiation and metastasis
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Nature
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Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by the HAS2-HYAL2/CD44 system on the plasma membrane.
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International journal of oncology
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Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants.
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The Journal of pharmacology and experimental therapeutics
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SORCS1 Alters Amyloid Precursor Protein Processing and Variants May Increase Alzheimer's Disease Risk
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Annals of neurology
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Developmental Regulation of TAC1 in Peptidergic-Induced Human Mesenchymal Stem Cells: Implication for Spinal Cord Injury in Zebrafish
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Stem Cells and Development
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A Mild Form of SLC29A3 Disorder: A Frameshift Deletion Leads to the Paradoxical Translation of an Otherwise Noncoding mRNA Splice Variant
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PLoS ONE
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The Relationship of Thioredoxin-1 and Cisplatin Resistance: Its Impact on ROS and Oxidative Metabolism in Lung Cancer Cells
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Molecular Cancer Therapeutics
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Stable Expression of Recombinant Factor VIII in CHO Cells Using Methotrexate-Driven Transgene Amplification
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Acta Naturae
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Regulation of platelet myosin light chain ( MYL9 ) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency
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Blood
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Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228.
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Life sciences
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Selective Toxicity of the Anthelmintic Emodepside Revealed by Heterologous Expression of Human KCNMA1 in Caenorhabditis elegans S⃞
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Molecular Pharmacology
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Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I
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Virology Journal
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Analysis of the active site mechanism of Tyrosyl-DNA phosphodiesterase I: a member of the phospholipase D superfamily
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Journal of Molecular Biology
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An 11p15 Imprinting Centre Region 2 Deletion in a Family with Beckwith Wiedemann Syndrome Provides Insights into Imprinting Control at CDKN1C
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PLoS ONE
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Thiopurine Methyltransferase Predicts the Extent of Cytotoxicty and DNA Damage in Astroglial Cells after Thioguanine Exposure
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PLoS ONE
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Dihydroceramide-based Response to Hypoxia *
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The Journal of Biological Chemistry
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Chromatin Remodeler Sucrose Nonfermenting 2 Homolog (SNF2H) Is Recruited onto DNA Replication Origins through Interaction with Cdc10 Protein-dependent Transcript 1 (Cdt1) and Promotes Pre-replication Complex Formation *
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The Journal of Biological Chemistry
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MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGF?R2) in colon cancer cells
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Carcinogenesis
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The Journal of Pharmacology and Experimental Therapeutics
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Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics
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Pharmacogenetics and genomics
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TIEG1 Inhibits Breast Cancer Invasion and Metastasis by Inhibition of Epidermal Growth Factor Receptor (EGFR) Transcription and the EGFR Signaling Pathway
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Molecular and Cellular Biology
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Altered Expression of Insulin Receptor Isoforms in Breast Cancer
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PLoS ONE
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Proteolytic and genetic variation of the alpha-2-antiplasmin C-terminus in myocardial infarction.
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Blood
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A novel expression and purification system for the production of enzymatic and biologically active human granzyme B.
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Journal of immunological methods
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Structural Basis for Matrix Metalloproteinase-2 (MMP-2)-selective Inhibitory Action of ?-Amyloid Precursor Protein-derived Inhibitor *
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The Journal of Biological Chemistry
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Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders
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Molecular Neurodegeneration
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Lemur tyrosine kinase-2 signalling regulates kinesin light chain-2 phosphorylation and binding of Smad2 cargo
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Oncogene
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Methyl 2-Cyano-3,12-dioxooleana-1,9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a
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Molecular Pharmacology
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USP13 Enzyme Regulates Siah2 Ligase Stability and Activity via Noncatalytic Ubiquitin-binding Domains *
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The Journal of Biological Chemistry
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Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells
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The Journal of Experimental Medicine
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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
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The Journal of Experimental Medicine
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Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site
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Nature communications
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TRPC6 mutations in children with steroid-resistant nephrotic syndrome and atypical phenotype.
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Clinical journal of the American Society of Nephrology : CJASN
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Parkin Interacts with Ambra1 to Induce Mitophagy
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The Journal of Neuroscience
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Contribution of Xanthine Oxidoreductase to Mammary Epithelial and Breast Cancer Cell Differentiation In Part Modulates Inhibitor of Differentiation-1
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Molecular cancer research : MCR
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KCNQ5/Kv7.5 potassium channel expression and subcellular localization in primate retinal pigment epithelium and neural retina
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American Journal of Physiology - Cell Physiology
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Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition
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Genome Research
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Phosphorylation via PKC Regulates the Function of the Drosophila Odorant Co-Receptor
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Frontiers in Cellular Neuroscience
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A Drosophila Model for Genetic Analysis of Influenza Viral/Host Interactions
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Genetics
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Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia.
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The Journal of investigative dermatology
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Distinct roles for Wnt-4 and Wnt-11 during retinoic acid-induced neuronal differentiation.
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Stem cells (Dayton, Ohio)
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Collagen XXIII--a potential biomarker for the detection of primary and recurrent non-small cell lung cancer
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
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Inhibition of Histone Lysine Methylation Enhances Expression of Cancer-Testis Genes in Lung Cancer Cells: Implications for Adoptive Immunotherapy of Cancer
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Cancer research
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The Role of Raf Kinase Inhibitor Protein in Rheumatoid Fibroblast-like Synoviocytes Invasiveness and Cytokine and Matrix Metalloproteinase Expression
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Inflammation
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Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
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Molecular Cancer
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RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene ( ALOX12 ): studies in human RUNX1 haplodeficiency
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Blood
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Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor.
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The Journal of pharmacology and experimental therapeutics
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A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas
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The Journal of Experimental Medicine
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Olfactomedin 2: Expression in the Eye and Interaction with Other Olfactomedin Domain-Containing Proteins
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Investigative Ophthalmology & Visual Science
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Time-resolved Fluorescence Resonance Energy Transfer (TR-FRET) to Analyze the Disruption of EGFR/HER2 Dimers
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The Journal of Biological Chemistry
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The Cancer/Testis Antigen Prostate-associated Gene 4 (PAGE4) Is a Highly Intrinsically Disordered Protein *
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The Journal of Biological Chemistry
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A microRNA expression signature of osteoclastogenesis
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Blood
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Regulator of G Protein Signaling 5 Is Highly Expressed in Parathyroid Tumors and Inhibits Signaling by the Calcium-Sensing Receptor
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Molecular Endocrinology
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A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis
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PLoS ONE
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Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.
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The Journal of pharmacology and experimental therapeutics
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Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells.
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Toxicology and applied pharmacology
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SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans
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Diabetes
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Molecular analysis of the SRD5A2 in 46,XY subjects with incomplete virilization: the P212R substitution of the steroid 5alpha-reductase 2 may constitute an ancestral founder mutation in Mexican patients.
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Journal of andrology
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SLUG-induced Elevation of D1 Cyclin in Breast Cancer Cells through the Inhibition of Its Ubiquitination *
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The Journal of Biological Chemistry
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A rapid assay for assessment of sphingosine kinase inhibitors and substrates
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Analytical biochemistry
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The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway
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Oncogene
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Platelet PKC-? deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1
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Arteriosclerosis, thrombosis, and vascular biology
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Activation of the aryl hydrocarbon receptor AhR promotes retinoic acid-induced differentiation of myeloblastic leukemia cells by restricting expression of the stem cell transcription factor Oct4
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Cancer Research
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PCDH8 , the human homolog of PAPC , is a candidate tumor suppressor of breast cancer
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A new concept underlying stem cell lineage skewing that explains the detrimental effects of thiazolidinediones on bone.
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Stem cells (Dayton, Ohio)
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Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury
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The FASEB Journal
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The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1
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Biochemical Journal
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HLA-DP, HLA-DQ, and HLA-DR Have Different Requirements for Invariant Chain and HLA-DM *
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The Journal of Biological Chemistry
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JUN-CCAAT/Enhancer-Binding Protein Complexes Inhibit Surfactant-Associated Protein B Promoter Activity
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American Journal of Respiratory Cell and Molecular Biology
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High-Throughput Screening Reveals a Small-Molecule Inhibitor of the Renal Outer Medullary Potassium Channel and Kir7.1
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Molecular Pharmacology
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Phosphoinositides are essential co-activators for p21-activated kinase 1 (Pak1)
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Molecular cell
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Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients
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The Journal of Clinical Investigation
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Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling
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Proceedings of the National Academy of Sciences of the United States of America
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Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma
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Molecular Cancer
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BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells
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Nucleic Acids Research
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Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim
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PLoS ONE
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Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q
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British Journal of Pharmacology
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Transcriptional activation of human mu-opioid receptor gene by insulin-like growth factor-I in neuronal cells is modulated by the transcription factor REST.
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Journal of neurochemistry
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c-Cbl Facilitates Endocytosis and Lysosomal Degradation of Cystic Fibrosis Transmembrane Conductance Regulator in Human Airway Epithelial Cells *
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The Journal of Biological Chemistry
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Transcription factor REST negatively influences the protein kinase C-dependent up-regulation of human mu-opioid receptor gene transcription.
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Neurochemistry international
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AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2
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Blood
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Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by the X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis.
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Journal of dermatological science
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Mammalian Target of Rapamycin (mTOR) and S6 Kinase Down-regulate Phospholipase D2 Basal Expression and Function
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The Journal of Biological Chemistry
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Protein kinase C? regulation of translocator protein (18 kDa) Tspo gene expression is mediated through a MAPK pathway targeting STAT3 and c-Jun transcription factors †
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Biochemistry
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Arylsulfatase B regulates interaction of chondroitin-4-sulfate and kininogen in renal epithelial cells.
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Biochimica et biophysica acta
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The ERK5 and ERK1/2 signaling pathways play opposing regulatory roles during chondrogenesis of adult human bone marrow-derived multipotent progenitor cells.
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Journal of cellular physiology
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The Oncogenic Phosphatase WIP1 Negatively Regulates Nucleotide Excision Repair
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DNA repair
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Ectopic Matrix Metalloproteinase 9 Expression in Human Brain Tumor Cells Enhances Oncolytic HSV Vector Infection
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Gene therapy
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TGFBI expression is associated with a better response to chemotherapy in NSCLC
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Molecular Cancer
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GABA Acts as a Ligand Chaperone in the Early Secretory Pathway to Promote Cell Surface Expression of GABAA Receptors
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Brain research
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PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.
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Nature cell biology
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Myc interacts with Max and Miz1 to repress C/EBP? promoter activity and gene expression
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Molecular Cancer
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Lipoprotein-associated phospholipase A2 decreases oxidized lipoprotein cellular association by human macrophages and hepatocytes.
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Biochimica et biophysica acta
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Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts
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Biochimica et biophysica acta
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Protein disulfide isomerase does not control recombinant IgG4 productivity in mammalian cell lines.
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Biotechnology and bioengineering
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TRPV4-mediated endothelial Ca 2+ influx and vasodilation in response to shear stress
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American Journal of Physiology - Heart and Circulatory Physiology
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HIF-1beta determines ABCA1 expression under hypoxia in human macrophages
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The International Journal of Biochemistry Cell Biology
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Characterization of Streptococcus pyogenes ?-NAD+ Glycohydrolase
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The Journal of Biological Chemistry
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Cell-specific targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus
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Retrovirology
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Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells by modulating PKC? phosphorylation
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International journal of cancer. Journal international du cancer
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Exogenous Expression of Caspase-14 Induces Tumor Suppression in Human Salivary Cancer Cells by Inhibiting Tumor Vascularization
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Anticancer research
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Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/?-Arrestin/cAMP Phosphodiesterase 4 Complex ▿
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Molecular and Cellular Biology
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Lack of effect of the ?2C-adrenoceptor Del322-325 polymorphism on inhibition of cyclic AMP production in HEK293 cells
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British Journal of Pharmacology
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I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule.
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Biochemical and biophysical research communications
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Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer
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Oncogene
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Identification of MAMDC1 as a Candidate Susceptibility Gene for Systemic Lupus Erythematosus (SLE)
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PLoS ONE
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The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts
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Significance of organic cation transporter 3 (SLC22A3) expression for the cytotoxic effect of oxaliplatin in colorectal cancer.
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Drug metabolism and disposition: the biological fate of chemicals
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Protective effect of concomitant administration of imatinib on cisplatin-induced nephrotoxicity focusing on renal organic cation transporter OCT2.
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Biochemical pharmacology
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Sphingosine kinase as a regulator of calcium entry through autocrine sphingosine 1-phosphate signaling in thyroid FRTL-5 cells.
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Endocrinology
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LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer
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Oncogene
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Effects of ranolazine, a novel anti-anginal drug, on ion currents and membrane potential in pituitary tumor GH(3) cells and NG108-15 neuronal cells.
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Journal of pharmacological sciences
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Oncogenic MicroRNA-27a Is A Target For Anticancer Agent Methyl 2-Cyano-3,11-dioxo-18?-olean-1,12-dien-30-oate in Colon Cancer Cells
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International journal of cancer. Journal international du cancer
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GATA4 is a regulator of astrocyte cell proliferation and apoptosis in the human and murine central nervous system.
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Oncogene
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Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation.
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Clinical & experimental metastasis
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Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.
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Biochimica et biophysica acta
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Identification of a Physiologically Relevant Endogenous Ligand for PPAR? in Liver
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Cell
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?7 Nicotinic Acetylcholine Receptor Regulates Airway Epithelium Differentiation by Controlling Basal Cell Proliferation
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The American Journal of Pathology
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SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability.
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Journal of cell science
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Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2.
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Biochemical pharmacology
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OTU Domain-containing Ubiquitin Aldehyde-binding Protein 1 (OTUB1) Deubiquitinates Estrogen Receptor (ER) ? and Affects ER? Transcriptional Activity *
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The Journal of Biological Chemistry
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Expression of the K303R Estrogen Receptor ? Breast Cancer Mutation Induces Resistance to an Aromatase Inhibitor via Addiction to the PI3K/Akt Kinase Pathway
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Cancer research
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NOS1AP Regulates Dendrite Patterning of Hippocampal Neurons through a Carboxypeptidase E-Mediated Pathway
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The Journal of neuroscience : the official journal of the Society for Neuroscience
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The Opposite Effects of Acute and Chronic Alcohol on Lipopolysaccharide-Induced Inflammation Are Linked to IRAK-M in Human Monocytes
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Journal of immunology (Baltimore, Md. : 1950)
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DEPTOR is an mTOR Inhibitor Whose Frequent Overexpression in Multiple Myeloma Cells Promotes their Survival
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Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.
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American journal of physiology. Cell physiology
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SCAMP5 Links Endoplasmic Reticulum Stress to the Accumulation of Expanded Polyglutamine Protein Aggregates via Endocytosis Inhibition
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The Journal of Biological Chemistry
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C/EBP-β Modulates Transcription of Tubulointerstitial Nephritis Antigen in Obstructive Uropathy
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Journal of the American Society of Nephrology : JASN
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BMP-2 signaling in ovarian cancer and its association with poor prognosis
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Journal of Ovarian Research
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S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling
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Endocrinology
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RE-1-silencing transcription factor shows tumor-suppressor functions and negatively regulates the oncogenic TAC1 in breast cancer cells
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Proceedings of the National Academy of Sciences of the United States of America
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Leptin Inhibits Glycogen Synthase Kinase-3? to Prevent Tau Phosphorylation in Neuronal Cells
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Neuroscience letters
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Imprinted CDKN1C Is a Tumor Suppressor in Rhabdoid Tumor and Activated by Restoration of SMARCB1 and Histone Deacetylase Inhibitors
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PLoS ONE
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Aberrant Methylation and Reduced Expression of LHX9 in Malignant Gliomas of Childhood 1
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Neoplasia (New York, N.Y.)
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Polo-like Kinase 2 (PLK2) Phosphorylates ?-Synuclein at Serine 129 in Central Nervous System *Polo-like Kinase 2 (PLK2) Phosphorylates ?-Synuclein at Serine 129 in Central Nervous System * S⃞
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The Journal of Biological Chemistry
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Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies.
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Molecular immunology
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Phorbol-12-myristate 13-acetate acting through protein kinase Cε induces translocator protein (18-kDa) Tspo gene expression †
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,PubMed ID 18975922
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The Parkinson’s disease associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity
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Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.
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Biochemical pharmacology
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Phenotypic and Functional Analysis of Human SLC26A6 Variants in Patients With Familial Hyperoxaluria and Calcium Oxalate Nephrolithiasis
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cAMP-dependent Protein Kinase A (PKA) Signaling Induces TNFR1 Exosome-like Vesicle Release via Anchoring of PKA Regulatory Subunit RII? to BIG2 *
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TGF-? Utilizes SMAD3 to Inhibit CD16-Mediated IFN-? Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells 1
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Journal of immunology (Baltimore, Md. : 1950)
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Potent activation of large-conductance Ca2+-activated K+ channels by the diphenylurea 1,3-bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) in pituitary tumor (GH3) cells.
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Molecular pharmacology
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AUF1 and HuR Proteins Stabilize Interleukin-8 mRNA in Human Saliva
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Journal of dental research
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Four Ca2+ Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate
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The Journal of General Physiology
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The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia.
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American journal of physiology. Lung cellular and molecular physiology
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Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins
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Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels.
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Nature
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The Roc Domain of Leucine-Rich Repeat Kinase 2 (LRRK2) is Sufficient for Interaction with Microtubules
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Journal of neuroscience research
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Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in Caucasian patients with androgen-independent prostatic cancer
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Clinical cancer research : an official journal of the American Association for Cancer Research
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Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships.
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Journal of medicinal chemistry
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SMAD proteins control DROSHA-mediated microRNA maturation
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Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation.
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Cancer
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In vivo delivery of lentiviral vectors expressing vasoactive intestinal peptide complementary DNA as gene therapy for collagen-induced arthritis.
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Arthritis and rheumatism
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Voltage Gating at the Selectivity Filter of the Ca2+ Release-activated Ca2+ Channel Induced by Mutation of the Orai1 Protein *
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The Journal of Biological Chemistry
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Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases.
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The FEBS journal
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Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A
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Blood
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Targeted tyrosine iodination in a multi-tyrosine vasopressin analog.
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Journal of peptide science : an official publication of the European Peptide Society
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Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells
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Cell Proliferation
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N-MYC IS A NOVEL REGULATOR OF PI3K-MEDIATED VEGF EXPRESSION IN NEUROBLASTOMA
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The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells
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Aging-Associated Truncated Form of p53 Interacts with Wild-Type p53 and Alters p53 Stability, Localization, and Activity
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Mechanisms of ageing and development
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R7-binding protein targets the G protein ?5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain
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BMC Biochemistry
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Hepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma Protein
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PLoS Pathogens
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Identification of Novel Human Cdt1-binding Proteins by a Proteomics Approach: Proteolytic Regulation by APC/CCdh1
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Molecular Biology of the Cell
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A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications.
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Journal of immunology (Baltimore, Md. : 1950)
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Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus.
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Journal of cellular physiology
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Serotonin inhibits neuronal excitability by activating two-pore domain k+ channels in the entorhinal cortex.
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Molecular pharmacology
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TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells--Mechanisms behind a possible new "hot" cancer treatment.
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Biochimica et biophysica acta
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Effect of clebopride, antidopaminergic gastrointestinal prokinetics, on cardiac repolarization.
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International journal of toxicology
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A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells
,null,
BMC Systems Biology
,PubMed ID 17498300
|
MOLECULAR MECHANISM OF HUMAN NRF2 ACTIVATION AND DEGRADATION: ROLE OF SEQUENTIAL PHOSPHORYLATION BY PROTEIN KINASE CK2
,null,
,PubMed ID 17512459
|
Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail.
,null,
Journal of cell science
,PubMed ID 17003104
|
Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).
,null,
The Journal of pharmacology and experimental therapeutics
,PubMed ID 16914559
|
LRRK2 in Parkinson's disease and dementia with Lewy bodies
,null,
Molecular Neurodegeneration
,PubMed ID 17137507
|
The cytoplasmic domain of NrCAM binds to PDZ domains of synapse-associated proteins SAP90/PSD95 and SAP97.
,null,
The European journal of neuroscience
,PubMed ID 16882004
|
CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor
,null,
,PubMed ID 17250586
|
Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity
,null,
,PubMed ID 16288226
|
Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.
,null,
Drug metabolism and pharmacokinetics
,PubMed ID 16272756
|
Increased Expression in Dorsolateral Prefrontal Cortex of CAPON in Schizophrenia and Bipolar Disorder
,null,
PLoS Medicine
,PubMed ID 16146415
|
Targeted Disruption of Fibulin-4 Abolishes Elastogenesis and Causes Perinatal Lethality in Mice
,null,
Molecular and Cellular Biology
,PubMed ID 16478991
|
Direct in vitro selection of a 2'-O-methyl aptamer to VEGF.
,null,
Chemistry & biology
,PubMed ID 15664512
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Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin.
,null,
European journal of pharmacology
,PubMed ID 15814084
|
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3K?
,null,
The Journal of Experimental Medicine
,PubMed ID 15824082
|
A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action.
,null,
Molecular endocrinology (Baltimore, Md.)
,PubMed ID 11518808
|
Application of fluorescence resonance energy transfer to study syndecan-3 signaling on the surface of neural cells
,Kulesskiy, E;,
Thesis May 2015
[PCMV6XL4]
|
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