MEK5 (MAP2K5) (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 14B5]

Specifications

Product Data
Clone Name	14B5
Applications	WB
Recommend Dilution	Western Blot: 0.5 µg/ml for HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubation buffer. Positive Control: Cell lysate from untreated A431 cells.
Reactivity	Canine, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide conjugated to hemocyanin
Specificity	This antibody reacts to MKK5.
Formulation	1 ml PBS / 0.09 % Na-azide / PEG and Sucrose State: Purified State: Lyophilized purified IgG
Reconstitution Method	Restore with 1 ml H2O (15 min, RT).
Purification	Size exclusion chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized (preferably in a desiccator) at -20°C and reconstituted (aliquote and freeze in liquid nitrogen) at -80°C. Avoid repeated freezing and thawing. Thaw aliquots at 37°C. Thawed aliquots may be stored at 4°C up to 3 months.
Gene Name	mitogen-activated protein kinase kinase 5
Database Link	Entrez Gene 5607 Human UniProt ID Q13163
Background	Mitogen-activated protein kinase kinase 5 (MKK5) belongs to the serine/threonine protein kinase family and the MAPK subfamily (MAP2K, MKK or MEKs). MKK5 specifically phosphorylates erk5/MAPK7 within the kinase activation loop pThr-E-pTyr motif. After activation erk5 phosphorylates MKK5 on multiple phosphoserine residues. The MKK5/erk5 pathway may play an important role in prostate and breast cancer.
Synonyms	MAP kinase kinase 5, MAPKK 5, MEK5, MKK5
Reference Data

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