p75 NGF Receptor (NGFR) (1-160) Mouse Monoclonal Antibody [Clone ID: NGFR5]

Specifications

Product Data
Clone Name	NGFR5
Applications	FC, IF, IHC, IP, WB
Recommend Dilution	Flow Cytometry. Immunoprecipitation. Western blot. Immunohistochemistry on Paraffin Sections: 1-2 μg/ml (Heat-mediated antigen retrieval required). Positive Control: melanoma tissue. Immunocytochemistry.
Reactivity	Feline, Ferret, Human, Monkey, Rabbit
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified CD271 protein isolated from Human melanoma cell line A875
Specificity	This antibody recognizes CD271/NGFR, a transmembrane glycoprotein of the TNFR superfamily. The epitope is localized within amino acids 1-160. Cellular Localization: Cell Surface, Cytoplasmic.
Formulation	PBS, pH~7.4 State: Purified State: Liquid purified Ig fraction from Cell Culture Supernatant (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Predicted Protein Size	75 kDa
Gene Name	nerve growth factor receptor
Database Link	Entrez Gene 4804 Human UniProt ID P08138
Background	CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.
Synonyms	TNFRSF16
Reference Data

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