ITGB2 Mouse Monoclonal Antibody [Clone ID: PNK-I]

Specifications

Product Data
Clone Name	PNK-I
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl of neat antibody to label 10e6 cells in 100 µl.
Reactivity	Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	Porcine large granular lymphocytes. Spleen cells from immunised Balb/c mice were fused with cells of the mouse P3-X63-Ag8.653 myeloma cell line.
Specificity	This antibody recognises the Porcine homologue of Human CD18. Clone PNK-I immunoprecipitates molecules of 166, 155 and 95 kDa under reducing and non-reducing conditions. Clone PNK-I has been reported to inhibit Porcine NK activity without affecting antibody-dependent cellular cytoxicity.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide and 1% BSA and 5% Sucrose Label: PE State: Lyophilized purified Ig fraction Label: R. Phycoerythrin (RPE)
Reconstitution Method	Restore with 1.0 ml distilled water.
Purification	Affinity chromatography on Protein G
Conjugation	PE
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Database Link	UniProt ID P53714
Background	CD18 is an integrin. Integrins are integral cell surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA1, and combines with the alpha M chain to form the integrin Mac1. Integrins are known to participate in cell adhesion as well as cell surface mediated signalling. CD18 is expressed by most leucocytes. Defects in the CD18 gene result in leukocyte adhesion deficiency.
Synonyms	Integrin beta-2, MFI7
Reference Data

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