Adiponectin (ADIPOQ) Mouse Monoclonal Antibody [Clone ID: M14-6 (A)-H11]

Specifications

Product Data
Clone Name	M14-6 (A)-H11
Applications	ELISA
Recommend Dilution	ELISA.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Adiponectin from E. coli
Specificity	This antibody detects Adiponectin.
Formulation	PBS pH 7,4 State: Purified State: Lyophilized Ig fraction
Reconstitution Method	Restore in aqua bidest to 1 mg/ml.
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2 - 8 °C and reconstituted at -20 °C. Avoid repeated freezing and thawing.
Gene Name	adiponectin, C1Q and collagen domain containing
Database Link	Entrez Gene 9370 Human UniProt ID Q15848
Background	Adipose cells produce and secrete numerous physiologically important proteins, such as Lipoprotein Lipase, Leptin, and Adipocyte Complement Related protein of 30 kDa, also known as Acrp30 or Adiponectin. Adiponectin is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, Adiponectin mRNA is induced >100 fold. Adiponectin improves the ability of insulin to suppress glucose production, at sub physiological levels, thereby linking adipose tissue to whole body glucose regulation. Adiponectin function appears to be regulated by phosphatidylinositol 3 kinase (PI3K) since Adiponectin secretion is blocked by pharmacologic inhibitors of this kinase. Adiponectin mRNA is significantly reduced in adipose tissue of obese patients with Type 2 diabetes. The structural similarity of Adiponectin to TNF alpha suggests that Adiponectin may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Adiponectin is implicated as a regulator of whole body energy homeostasis.
Synonyms	ADIPOQ, ACDC, ACRP30, APM1, GBP28
Reference Data

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