DcR1 (TNFRSF10C) Mouse Monoclonal Antibody [Clone ID: TRAIL-R3-02]

Specifications

Product Data
Clone Name	TRAIL-R3-02
Applications	FC
Recommend Dilution	Flow Cytometry: 3 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	TRAIL-R3 (aa 1-280) - hIgGhc fusion protein
Specificity	The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Formulation	PBS containing 15 mM Sodium Azide as preservative and 0.2% (w/v) high-grade BSA (Protease free) as stabilizer. Label: PE State: Liquid purified IgG fraction. Label: Conjugated with R-Phycoerythrin under optimum conditions
Concentration	lot specific
Purification	Size-Exclusion Chromatography.
Conjugation	PE
Storage Condition	Store the antibody in the dark at 2-8°C. DO NOT FREEZE! Avoid prolonged exposure to light.
Gene Name	tumor necrosis factor receptor superfamily member 10c
Database Link	Entrez Gene 8794 Human UniProt ID O14798
Background	TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).
Synonyms	Decoy receptor 1, TNFRSF10C, DCR1, LIT, TRID, TRAIL receptor 3, TRAIL-R3
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.