CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: MEM-229]
CAT#: AM03092BT-N
CD105 (ENG) mouse monoclonal antibody, clone MEM-229, Biotin
Conjugation: Unconjugated FITC PE
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CNY 3,810.00
Specifications
Product Data | |
Clone Name | MEM-229 |
Applications | FC, IF |
Recommend Dilution | Indirect immunofluorescence analysis by Flow Cytometry. |
Reactivity | Human, Porcine |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA. |
Specificity | This antibody recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy. |
Formulation | PBS, pH~7.4 with 0.2 % BSA Label: Biotin State: Liquid purified Ig fraction Preservative: 15 mM Sodium Azide Label: Conjugated with -LC-NHS under optimum conditions. The reagent is free of unconjugated biotin |
Concentration | lot specific |
Conjugation | Biotin |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | endoglin |
Database Link | |
Background | CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
Synonyms | ENG, END, HHT1, ORW, ORW1 |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
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