CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: MEM-229]
CAT#: AM03092PU-N
CD105 (ENG) mouse monoclonal antibody, clone MEM-229, Purified
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CNY 3,280.00
货期*
5周
规格
Cited in 4 publications. |
Specifications
Product Data | |
Clone Name | MEM-229 |
Applications | FC, IF, IHC, WB |
Recommend Dilution | Flow Cytometry: 10 μg/ml. Positive Control: Kg1 Human acute myelogenous leukemia cell line. Western Blotting (Non-Reducing Conditions). Immunocytochemistry. Immunohistochemistry on Frozen Sections: 1/200 (Acetone Fixation). |
Reactivity | Human, Porcine |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA. |
Specificity | The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy. |
Formulation | PBS, pH~7.4 State: Purified State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide |
Concentration | lot specific |
Purification | Protein-A Affinity Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | endoglin |
Database Link | |
Background | CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFβR-2 as a receptor for TGFβ-1 and TGFβ-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFβ-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
Synonyms | ENG, END, HHT1, ORW, ORW1 |
Reference Data |
Citations (4)
The use of this Antibodies has been cited in the following citations: |
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Enhanced inhibition of tumor growth using TRAIL-overexpressing adipose-derived stem cells in combination with chemotherapeutic agent CPT-11 in castration-resistant prostate cancer
,Kim, J;Oh, E;Han, Y;Lee, S;Song, Y;,
Prostate International
[ENG]
|
Tissue Engineered Esophageal Patch by Mesenchymal Stromal Cells: Optimization of Electrospun Patch Engineering
,Pisani, S;Croce, S;Chiesa, E;Dorati, R;Lenta, E;Genta, I;Bruni, G;Mauramati, S;Benazzo, A;Cobianchi, L;Morbini, P;Caliogna, L;Benazzo, M;Avanzini, MA;Conti, B;,
Int J Mol Sci
,PubMed ID 32143536
[ENG]
|
Enhancement of Bone Marrow Aspirate Concentrate with Local Self-healing Corticotomies
,Shi, L;Tee, B;Emam, H;Prokes, R;Larsen, P;Sun, Z;,
Tissue and Cell
[ENG]
|
Use of allogenic stem cells for the prevention of bone bridge formation in miniature pigs
,Planka L, Necas A, Srnec R, Rauser P, Star} D, Jancar J, Amler E, Filova E, Hlucilova J, Kren L, Gal P,
Physiol Res
,PubMed ID 19093735
[ENG]
|
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