Hsp105 (HSPH1) (Isoform alpha) Mouse Monoclonal Antibody [Clone ID: J1G12]

Specifications

Product Data
Clone Name	J1G12
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot: 1:500 ~ 1,000 (starting dilution 1:1000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human HSP105 α (1-858 aa) purified from E. coli
Specificity	This antibody detects Heat Shock Protein 105 alpha (HSP105a).
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	heat shock protein family H (Hsp110) member 1
Database Link	Entrez Gene 10808 Human UniProt ID Q92598
Background	Hsp105 is a mammalian member of the HSP105/110 family, a diverged subgroup of the HSP70 family. HSP105 exists as two isoforms, alpha and beta. Hsp105 alpha associates with Hsp70/Hsc70 as complexes in vivo and regulates the chaperone activity of Hsp70/Hsc70 negatively in vitro and in vivo. Hsp105 α is constitutively expressed and also induced by various stress, whereas Hsp105 β, lacking 44 amino acids from Hsp105 α, is specifically expressed during mild heat shock. Although Hsp105 α is shown to localize in the cytoplasm of mammalian cells, cellular localization of Hsp105 β is not known.
Synonyms	Heat shock 110 kDa protein, Antigen NY-CO-25, HSPH1, HSP-105, HSP110, KIAA0201
Reference Data

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