Rb2 p130 (RBL2) Mouse Monoclonal Antibody [Clone ID: KAB40]

Specifications

Product Data
Clone Name	KAB40
Applications	WB
Recommend Dilution	Suitable for Western Blots at 1/1000.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	GST fusion protein to the N terminus of p130.
Specificity	This antibody recognizes both the phosphorylated and unphosphorylated forms of p130 at a MW of 130 kDa.
Formulation	PBS containing 0.08% Sodium Azide as preservative. State: Purified State: Liquid (sterile filtered) purified IgG fraction.
Concentration	lot specific
Purification	Protein A/G chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	RB transcriptional corepressor like 2
Database Link	Entrez Gene 5934 Human UniProt ID Q08999
Background	P130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors.
Synonyms	Retinoblastoma-like protein 2, RB2, 130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2
Reference Data

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