CD70 Mouse Monoclonal Antibody [Clone ID: Bu69]

Specifications

Product Data
Clone Name	Bu69
Applications	FC, IF, IHC
Recommend Dilution	Flow Cytometry: Use 10 µl of 1/50-1/200 diluted antibody to label 10e6 cells in 100 µl. Immunohistochemistry on Frozen Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognizes CD70, a 29kD type II transmembrane protein that belongs to the tumour necrosis factor (TNF) family. CD70 is expressed on a small number of activated T-cells and the majority of activated B-cells. Interaction of CD70 with its receptor, CD27, is thought to play an important role in lymphocyte activation, proliferation, survival and differentiation. The antibody Clone Bu69 has been used for the inhibition of neural stem cell induced apoptosis of allogeneic T cells in vitro (Lee et al. 2013).
Formulation	Phosphate buffered saline pH 7.4 containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD70 molecule
Database Link	Entrez Gene 970 Human UniProt ID P32970
Background	CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
Synonyms	CD27 ligand, CD27L, CD27LG, TNFSF7
Reference Data
Protein Families	ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction

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