Complement C3 (C3) (Neoantigen, iC3b) Mouse Monoclonal Antibody [Clone ID: 013III-1.16]

Specifications

Product Data
Clone Name	013III-1.16
Applications	ELISA, FC, IHC, WB
Recommend Dilution	ELISA. Western blot. Flow Cytometry. Immunohistochemistry on Frozen Sections. Histology Positive Control Tissue: Kidney from post streptoccal glomerulonephritis patients.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Human iC3b
Specificity	AM05608PU-N Recognises 42kDa inactive complement component 3b (iC3b) neoantigen present in blood serum.
Formulation	Borate buffered saline pH 8.2-8.4 State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement component 3
Database Link	Entrez Gene 718 Human UniProt ID P01024
Background	Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin. This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated. iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10. It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses. Additionally iC3b acts as an opsonin which is recognised by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosis and Rheumatoid arthritis.
Synonyms	CPAMD1, Complement component 3
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Complement and coagulation cascades, Systemic lupus erythematosus

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