hspX (16 kDa Ag) Mouse Monoclonal Antibody [Clone ID: 5175]

Specifications

Product Data
Clone Name	5175
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot.
Reactivity	Mycobacterium tuberculosis
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody is specific for the 16 kDa antigen of Mycobacterium tuberculosis and Mycobacterium bovis. M. tuberculosis is the common causative agent of tuberculosis in humans. M. bovis is a closely related species which causes tuberculosis in cattle.
Formulation	Phosphate buffered saline, 0.09% Sodium Azide (NaN3) State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
Database Link	UniProt ID P0A5B7
Background	Mycobacterium tuberculosis is the most common cause of tuberculosis. Primary infection begins with inhalation of 1 to 10 aerosolised bacilli. The pathogenicity of the organism is determined by its ability to escape host immune responses as well as eliciting delayed hypersensitivity. Alveolar macrophages engulf the invading cells but are unable to mount an effective defense. Several virulence factors are responsible for this apparent failure; most notably in the mycobacterial cell wall are the cord factor, lipoarabinomannan, and the 65 kd heat shock protein or HSP65. The emergence of new strains of resistant Mycobacterium tuberculosis has created new interest in clinical diagnosis. Studies have shown immunohistochemical techniques to be superior to conventional special stains. Thus the demonstration of mycobacterial antigens are not only useful in establishing mycobacterial aetiology, but can also be used as an alternative method to the conventional Ziehl-Neelsen method.
Synonyms	M. tuberculosis, TB
Reference Data

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