CD59 Mouse Monoclonal Antibody [Clone ID: 1F5]

Specifications

Product Data
Clone Name	1F5
Applications	FC
Recommend Dilution	Tissue Distribution by Flow Cytometry Analysis: Cell Concentration: 1x10e6 cells per test Antibody Concentration Used: 1.0μg/10e6 cells Cell Source: RBC 100% Lymphocytes 80.2%
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Mouse pre-B tumour cells (RAW112) Donor: Lewis rat spleen Fusion Partner: S 194/5. XXO. BU-1
Specificity	This antibody reacts to CD59.
Formulation	Biotin conjugated IgG buffered in PBS, 0.02% sodium azide and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. Label: Biotin State: Liquid purified Ig fraction
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD59 molecule
Database Link	Entrez Gene 966 Human UniProt ID P13987
Background	CD59 (also known as HRF20, protectin) is a 20 kDa glycoprotein attached to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It blocks MAC formation in the complement pathway by interfering with C9 membrane insertion and polymerization, but it does not affect the generation of C3 and C5 activation products. CD59 is expressed on several cell types, including leukocytes, endothelial and epithelial cells, erythrocytes, and cells of the central nervous system. CD59 belongs to the Ly6 superfamily of proteins.
Synonyms	MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21, MACIF, MAC-IP, MIRL, HRF20, HRF-20
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Complement and coagulation cascades, Hematopoietic cell lineage

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