ORF45 ORF45 Mouse Monoclonal Antibody [Clone ID: 2D4A5]

CAT#: AM06086SU-N

ORF45 ORF45 mouse monoclonal antibody, clone 2D4A5, Ascites



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CNY 5,918.00


货期*
5周

规格
    • 100 ul

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Specifications

Product Data
Clone Name 2D4A5
Applications IF, WB
Recommend Dilution ELISA: 1/10000. 
Western Blot: 1/500 - 1/2000. 
Immunofluorescence: 1/200 - 1/1000. 
Immunohistochemistry: 1/200 - 1/1000.
Reactivity Kaposi-Sarkom-Herpesvirus
Host Mouse
Clonality Monoclonal
Immunogen Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
Specificity This antibody recognizes KSHV ORF45
Formulation State: Ascites
State: Ascitic fluid
Preservative: 0.03% Sodium Azide
Conjugation Unconjugated
Storage Condition

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Background Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
Synonyms KSHV, Human gammaherpesvirus 8, HHV-8
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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