Fibulin 5 (FBLN5) Mouse Monoclonal Antibody [Clone ID: 3F10A5]

Specifications

Product Data
Clone Name	3F10A5
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/10000.  Western Blot: 1/500-1/2000. Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Fibulin 5 expressed in E. Coli.
Specificity	Recognizes Human Fibulin 5 (FBLN5). Other species not tested.
Formulation	State: Ascites State: Ascitic fluid Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	fibulin 5
Database Link	Entrez Gene 10516 Human UniProt ID Q9UBX5
Background	Fibulin 5 (FBLN5), with 448-amino acid protein (about 50kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Synonyms	FIBL-5, FBLN5, DANCE, Urine p50 protein, UP50
Reference Data

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