Estrogen Receptor 1 (ESR1) Mouse Monoclonal Antibody [Clone ID: 5D4B1]

CAT#: AM06176SU-N

Estrogen Receptor 1 (ESR1) mouse monoclonal antibody, clone 5D4B1, Ascites



Need it in bulk or conjugated?
Get a free quote

CNY 4,536.00


货期*
5周

规格
    • 100 ul

Product images

Specifications

Product Data
Clone Name 5D4B1
Applications ELISA, WB
Recommend Dilution ELISA: 1/10000. 
Western Bloting: 1/500 - 1/2000.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Purified recombinant fragment of ER expressed in E. Coli.
Specificity Recognizes ER (Estrogen Receptor 1).
Formulation State: Ascites
State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation Unconjugated
Storage Condition

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Gene Name estrogen receptor 1
Background ER (Estrogen Receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites. Serines 104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ER activity. Ser118 may be the substrate of the transcription regulatory kinase cdK7. Ser167 may be phosphorylated by p90RSK and Akt. Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients.
Synonyms ER alpha, Estradiol receptor, ESR1, ESR, NR3A1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...