IMP3 (IGF2BP3) Mouse Monoclonal Antibody [Clone ID: 8F11]

Specifications

Product Data
Clone Name	8F11
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500-1/2000. Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human IGF2BP3 expressed in E. Coli.
Specificity	Recognizes  IGF2BP3 / IMP3
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	69 kDa
Gene Name	insulin like growth factor 2 mRNA binding protein 3
Database Link	Entrez Gene 10643 Human UniProt ID O00425
Background	The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism.Tissue specificity: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines .IMP-3 is a marker for carcinomas and high-grade dysplastic lesions of pancreatic ductal epithelium.
Synonyms	KOC1, VICKZ3
Reference Data

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