Tfrc Rat Monoclonal Antibody [Clone ID: RI7217]
CAT#: AM08050LE-N
Tfrc rat monoclonal antibody, clone RI7217, Low Endotoxin
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CNY 5,236.00
货期*
4周
规格
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Specifications
Product Data | |
Clone Name | RI7217 |
Applications | FC, FN, ICC, IP, WB |
Recommend Dilution | Flow Cytometry (Reported in literature). Westeren Blot (Reported in literature). Immunocytochemistry (Reported in literature). In vivo and vitro Inhibition of Cell Proliferation (Reported in literature). Immunoprecipitation (Reported in literature). |
Reactivity | Mouse |
Host | Rat |
Clonality | Monoclonal |
Specificity | This antibody recognises CD71/Transferrin Receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions). RI7217 inhibits cell proliferation in vitro. (Ref.2) |
Formulation | PBS without preservatives. State: Low Endotoxin State: Liquid purified Ig fraction. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Gene Name | transferrin receptor |
Database Link | |
Background | CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the Transferrin Receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain. |
Synonyms | TfR1, p90, Transferrin receptor protein 1 |
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