Cd80 Rat Monoclonal Antibody [Clone ID: 1G10]
CAT#: AM08052BT-N
Cd80 rat monoclonal antibody, clone 1G10, Biotin
Conjugation: Unconjugated APC FITC PE
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CNY 4,576.00
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Specifications
Product Data | |
Clone Name | 1G10 |
Applications | FC |
Recommend Dilution | Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.2,7) |
Reactivity | Mouse |
Host | Rat |
Clonality | Monoclonal |
Specificity | This antibody recognises CD80/B7-1 (Mr. 45-47 kDa) |
Formulation | PBS containing 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction. |
Concentration | lot specific |
Conjugation | Biotin |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. |
Gene Name | CD80 antigen |
Database Link | |
Background | CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor cross linking with peak expression occurring between 48 and 72 hours postactivation. (Ref.1-4) The interaction of CD80/B7-1 with its ligands, CD28 and CD152/CTLA-4, provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex. (Ref.5,6). This Monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80, but it does not block stimulation of T cells by natural antigenpresenting cells. (Ref.2,7). |
Synonyms | CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1 |
Reference Data |
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