CD45 / LCA (CD45RC) Rat Monoclonal Antibody [Clone ID: C455.1F]

Specifications

Product Data
Clone Name	C455.1F
Applications	FC
Recommend Dilution	Flow Cytometry: Identification and enumeration of CD45RC+ cells (< / = 1 µg/10e6 cells).
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Specificity	This antibody recognises an exon C-dependent epitope of CD45 glycoprotein.
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: FITC State: Liquid purified Ig fraction. Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	protein tyrosine phosphatase, receptor type, C
Database Link	Entrez Gene 19264 Mouse UniProt ID P06800
Background	The CD45 family of cell surface glycoprotein antigens exist as a set of isoforms. (Ref.1-4) The patterns of monoclonal antibody recognition of the CD45 phenotypes can be restricted (CD45RA, RB and RC), or broader, such as the CD45 T 200 species (See also products AM08044). (Ref.1-4)The "restricted" subsets of this group arise as a result of translation of alternatively spliced mRNAs from exons A, B and C (exons 4, 5 and 6), where exons 3-15 encode the extracellular domain of the CD45 molecule. The restricted epitopes are differentially expressed on T and B lymphocytes, including functionally distinct T cells. CD45 (LCA) is a transmembrane phosphotyrosine phosphatase expressed on leucocytes. Myeloid cells do not express the RC isoform.
Synonyms	PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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