MHC Class I H2 Kd/Dd Mouse Monoclonal Antibody [Clone ID: 34-1-2S]
CAT#: AM08081RP-N
MHC Class I H2 Kd/Dd mouse monoclonal antibody, clone 34-1-2S, PE
Conjugation: Unconjugated Biotin FITC
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CNY 4,169.00
Cited in 1 publication. |
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Specifications
Product Data | |
Clone Name | 34-1-2S |
Applications | FC, IHC |
Recommend Dilution | Flow Cytometry: < / = 1 µg/10e6 cells. Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections). |
Reactivity | Mouse |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | C3HalphaBDF1 mouse splenocytes. |
Specificity | This antibody is specific to an epitope in the alpha 3 domain that is common to H-2Kd and H-2Dd. It binds to a common determinant in the alpha 3 domains of H-2Kd and H-2Dd in the presence or absence of beta 2 Microglobulin. (Ref.7,8) It cross reacts with the alpha 3 domain of H-2Kb. (Ref.1,2) |
Formulation | PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent. Label: PE State: Liquid purified Ig fraction. Label: R-Phycoerythrin |
Concentration | lot specific |
Purification | Liquid purified Ig fraction. |
Conjugation | PE |
Storage Condition | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. |
Background | The 'classical' MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta 2-Microglobulin. (Ref.3,4) These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. (Ref.5) MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny. (Ref.3,6) |
Reference Data |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer
,Sakamoto, S;Inoue, H;Kohda, Y;Ohba, SI;Mizutani, T;Kawada, M;,
Int J Mol Sci
,PubMed ID 32668617
[MHC Class I H2 Kd/Dd]
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