Cytokeratin 8 (KRT8) (C-term) Mouse Monoclonal Antibody [Clone ID: SB37b]

Specifications

Product Data
Clone Name	SB37b
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: < / = 1-2 µg/ml. Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections): 10 µg/ml
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant C-terminal fragment of Keratin 8.
Specificity	This antibody reacts specifically with Cytokeratin 8 and recombinant C-terminal Keratin 8.
Formulation	100 mM Borate buffered saline, pH 8.0 without preservatives or amine-containing buffer salts. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	keratin 8
Database Link	Entrez Gene 3856 Human UniProt ID P05787
Background	Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30% sequence homology. (Ref.1-5) Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 8 (55 kDa) belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. It is expressed in all simple type epithelia tissues (e.g., liver, pancreas, kidney, gut epithelial lining) but not in stratified squamous epithelia. Cytokeratin 8 is also present in the majority of adenocarcinomas and ductal carcinomas but is absent in squamous cell carcinomas.
Synonyms	KRT8, CYK8, Cytokeratin-8, CK8, Keratin-8, K8, Cytokeratin endo A
Note	Chatacterization: To ensure acceptable performance, each batch of product is tested by ELISA, Immunohistochemical staining (HT29 and HCC38 cells) and Western blotting (HT29 and HCC38 cell lysates) to conform to characteristics of a standard reference reagent.
Reference Data

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