TDP1 Mouse Monoclonal Antibody [Clone ID: AT1F2]

Specifications

Product Data
Clone Name	AT1F2
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western blot: 1/1,000-1/2,000. Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human TDP1 (1-298 aa) purified from E. coli
Specificity	The antibody recognizes Human TDP1. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tyrosyl-DNA phosphodiesterase 1
Database Link	Entrez Gene 55775 Human UniProt ID Q9NUW8
Background	Tyrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that catalyzes the hydrolysis of a phophodiester bond between a tyrosine residue and a DNA 3' phosphate. This protein is a member of the phospholipase D (PLD) superfamily and contains two PLD phosphodiesterase domains. Mutations in TDP1 are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1) by interfering with DNA transcription or by inducting apoptosis in postmitotic neurons.
Synonyms	Tyrosyl-DNA phosphodiesterase 1
Reference Data
Protein Families	Druggable Genome

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