Thymidylate Synthase (TYMS) Mouse Monoclonal Antibody [Clone ID: AT1S5]

Specifications

Product Data
Clone Name	AT1S5
Applications	ELISA, IF, WB
Recommend Dilution	ELISA. Western blot (1:500 - 1:1,000). Immunofluorescence (1:500 - 1:1,000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant TYMS (1-313 aa) purified from E. coli
Specificity	The antibody recognizes human TYMS. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	thymidylate synthetase
Database Link	Entrez Gene 7298 Human UniProt ID P04818
Background	The methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dMTP) is an essential step for the formation of thymine nucleotides. This process is catalyzed by thymidylate synthase (TS or TYMS). TYMS is an intracellular enzyme that provides the sole de novo source of thymidylate in activity highest proliferating cells. Being the exclusive source of dTMP, TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU). 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head and neck. TS expression may be useful in predicting overall patient survival, but the prognostic value of TS expression continues to be a subject of investigation for different types of cancers.
Synonyms	TYMS, TSase, OK/SW-cl.29
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism

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