TUBB2B Mouse Monoclonal Antibody [Clone ID: AT5B3]

Specifications

Product Data
Clone Name	AT5B3
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Western blot: 1/250-1/500. Immunofluorescence: 1/250-1/500. Immunohistochemistry on Paraffin Embedded tissues: 1/50.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human TUBB2b (1-445aa) purified from E. coli.
Specificity	The antibody recognizes Human and Mouse TUBB2B. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tubulin beta 2B class IIb
Database Link	Entrez Gene 73710 MouseEntrez Gene 347733 Human UniProt ID Q9BVA1
Background	The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. Multiple beta Tubulin isoforms have been characterized and are expressed in mammalian tissues. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB2b is mainly expressed in developing neurons with a dominant expression during the critical steps of corticogenesis. Also, TUBB2B is a new critical gene involved in neuronal migration. It is present in the nuclei and nucleoplasm, Defects in this gene are a cause of asymmetric polymicrogyria.
Synonyms	Tubulin beta-2B chain, beta II Tubulin B, beta-Tubulin, RP11-506K6.1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Gap junction, Pathogenic Escherichia coli infection

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