Caveolin 1 (CAV1) (1-104) Mouse Monoclonal Antibody [Clone ID: AT4C1]

Specifications

Product Data
Clone Name	AT4C1
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA (starting dilution is 1:500). Western blot (1:250 - 1:1000, starting dilution is 1:500). Immunohistochemistry / Immunoflourescence. Flow cytometry.
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human CAV1 (1-104aa) purified from E. coli
Specificity	The antibody recognizes caveolin-1 at aa 1-104.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	caveolin 1
Database Link	Entrez Gene 25404 RatEntrez Gene 857 Human UniProt ID Q03135
Background	The identification of caveolin-1 (CAV1) as the main structural component of caveolae, together with the finding that CAV1 might serve as a molecular organizer for membrane multiprotein complexes involved in cellular traffic, endo-and transcytosis, cell adhesion and signal transduction prompted a new impulse in the research on these intracellular organells. One of the properties of CAV1 was its insolubility in cold non-ionic detergents together with apical markers in epithelial cell. Also, cholesterol is essential for caveolae formation and maintenance, and caveolae structure is highly sensitive to cholesterol depletion or treatment with cholesterol binding drugs. CAV1 tightly and specifically binds free cholesterol and artificial cholesterol containing vesicles.
Synonyms	CAV1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Focal adhesion, Viral myocarditis

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