Pyruvate Kinase (PKLR) Mouse Monoclonal Antibody [Clone ID: AT1E3]

Specifications

Product Data
Clone Name	AT1E3
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot (1:500).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human PKLR (47-574aa) purified from E. coli
Specificity	The antibody recognizes human PKLR. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	pyruvate kinase, liver and RBC
Database Link	Entrez Gene 5313 Human UniProt ID P30613
Background	PKLR is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. The PKLR gene encodes the L- and R-type isoenzymes through alternative splicing events under the control of different promoters. The L-type isoform also exists as a tetramer and is upregulated by glucose with implications in maturity-onset diabetes of the young.
Synonyms	PK1, PKL, Pyruvate kinase R/L, Pyruvate kinase 1, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Glycolysis / Gluconeogenesis, Insulin signaling pathway, Maturity onset diabetes of the young, Metabolic pathways, Purine metabolism, Pyruvate metabolism, Type II diabetes mellitus

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