Inhibin alpha (INHA) Mouse Monoclonal Antibody [Clone ID: R1]

Specifications

Product Data
Clone Name	R1
Applications	IHC
Recommend Dilution	Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/10-1/100 Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended. Use Polymer anti Mouse/Rabbit IgG as a detection system. Positive Control: Adrenal cortex, placenta, testis, corpus luteum.
Reactivity	Bovine, Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A synthetic peptide corresponding to amino acids 1-32 of Human Inhibin alpha subunit.
Specificity	Recognizes Inhibin alpha. Cellular Localization: Cytoplasmic.
Formulation	State: Supernatant State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	inhibin alpha subunit
Database Link	Entrez Gene 3623 Human UniProt ID P05111
Background	Inhibin is a dimeric glycoprotein hormone from TGF-beta family made up of alpha and beta subunits. It inhibits the production of follicle-stimulating hormone from pituitary while actively stimulates the production of FSH. It is suggested that inhibin may act as a gonadal tumor suppressor. Inhibin has 2 subunits (alpha and beta) that are coded by separate genes. The alpha subunit determines whether inhibin or activin will be produced. The alpha subunit remains constant, such that the various types of inhibin are defined by the beta subunit (a,b,c,d). Inhibin A is a dimer of alpha and beta A. Inhibin B is a dimer of alpha and beta B. Proteolytic processing yields a number of inhibin alpha bioactive forms: the 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N terminal propeptide linked through a disulfide bond to the mature alpha chain, and the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono or diglycosylated, causing the mass difference.
Synonyms	INHA
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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