KMT5A (N-term) Mouse Monoclonal Antibody [Clone ID: 43AT551.86]

Specifications

Product Data
Clone Name	43AT551.86
Applications	WB
Recommend Dilution	ELISA: 1/1,000. Western blotting: 1/100-1/500.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was raised using purified recombinant GST fusion protein encoding the N-terminal region of human SET07.
Specificity	This antibody is specific SET07.
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	lysine methyltransferase 5A
Database Link	Entrez Gene 387893 Human UniProt ID Q9NQR1
Background	SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.
Synonyms	SET8, PRSET7, PR-Set7, KMT5A
Reference Data

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