CD11a / ITGAL Rat Monoclonal Antibody [Clone ID: M17/4]

Specifications

Product Data
Clone Name	M17/4
Applications	FC
Recommend Dilution	Flow Cytometry:  3 µg/ml.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	C57BL/6 mouse splenic secondary cytotoxic T lymphocytes
Specificity	The rat monoclonal antibody M17/4 reacts with CD11a (alpha-subunit of murine LFA-1), a 180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 Label: FITC State: Liquid purified Ig fraction Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Database Link	UniProt ID P24063
Background	CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions.
Synonyms	Integrin alpha-L, LFA1, LFA-1
Reference Data

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