CD11a / ITGAL Rat Monoclonal Antibody [Clone ID: M17/4]

CAT#: AM12064PU-N

CD11a / ITGAL rat monoclonal antibody, clone M17/4, Aff - Purified

Conjugation: Unconjugated FITC



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AM12064PU-N is a replacement of TA320384.

CNY 2,480.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name M17/4
Applications FC, FN, IHC, IP
Recommend Dilution Flow Cytometry: 1 µg/ml.
Immunoprecipitation.
Immunohistochemistry on Frozen Sections (Acetone fixation).
Positive Control: Mouse spleen or thymus.
Functional Assays: Blocking.
Reactivity Mouse
Host Rat
Clonality Monoclonal
Immunogen C57BL/6 mouse splenic secondary cytotoxic T lymphocytes
Specificity The antibody reacts with CD11a (alpha-subunit of murine LFA-1), a 180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
Formulation PBS, pH~7.4
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
Preservative: 15 mM Sodium Azide
Concentration lot specific
Purification Purified by protein-G affinity chromatography.
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
Background CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions.
Synonyms Integrin alpha-L, LFA1, LFA-1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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