PDGF Receptor beta (PDGFRB) Mouse Monoclonal Antibody [Clone ID: 18A2]
CAT#: AM12129AC-N
PDGF Receptor beta (PDGFRB) mouse monoclonal antibody, clone 18A2, APC
Conjugation: Unconjugated PE
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CNY 4,340.00
Specifications
Product Data | |
Clone Name | 18A2 |
Applications | FC |
Recommend Dilution | Flow cytometry of human blood cells: 10 μl reagent / 100 μl of whole blood or 10e6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | CD140b-transfected NIH 3T3 cells |
Specificity | This antibody recognizes CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles. |
Formulation | Phosphate buffered saline (PBS) solution containing 15mM sodium azide Label: APC State: Liquid purified Ig fraction Label: Conjugated with cross-linked Allophycocyanin under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. |
Conjugation | APC |
Storage Condition | Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
Gene Name | platelet derived growth factor receptor beta |
Database Link | |
Background | CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma. |
Synonyms | PDGF-R-beta, PDGF Receptor beta |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
Protein Pathways | Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
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