IL1 Receptor I (IL1R1) (Extracell. Dom.) Mouse Monoclonal Antibody [Clone ID: 40101]

Specifications

Product Data
Clone Name	IL1-31-22.2.1
Applications	ELISA, IHC, R
Recommend Dilution	ELISA. Immunohistochemistry on Paraffin Sections: 10 µg/ml. RIA.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Extracellular domain of the type I Human IL-1 receptor
Specificity	These antibodies react with cell surface and soluble human IL-1 receptor. Specific epitopes are unknown, but they do partially inhibit (30-50%) binding of one another to IL-1 receptor. They do not block binding of IL-1 to receptor, and they do not cross-react with receptors for Human IL-2 or IL-4.
Formulation	PBS, pH 7.4 State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 1 receptor type 1
Database Link	Entrez Gene 3554 Human UniProt ID P14778
Background	IL1R is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. IL1R is a receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B. The gene for this protein and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
Synonyms	IL1R, IL1RA, IL1RT1, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type 1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway

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