BCL2 Mouse Monoclonal Antibody [Clone ID: BL-2]
CAT#: AM20590PU-N
BCL2 mouse monoclonal antibody, clone BL-2, Aff - Purified
Need it in bulk or conjugated?
Get a free quote
CNY 5,599.00
货期*
5周
规格
Cited in 1 publication. |
Specifications
Product Data | |
Clone Name | BL-2 |
Applications | IF, IHC, WB |
Recommend Dilution | Western Blot: 1 - 2 μg/ml. Immunocytochemistry. Immunohistochemistry on frozen and paraffin sections: 0.4 - 1 μg/ml. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Synthetic peptide corresponding to residues 41-54pf the bcl-2 protein, conjugated to thyroglobulin. |
Specificity | This antibody reacts to BCL2. |
Formulation | 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative. State: Aff - Purified State: Lyphilized purified Ig fraction |
Reconstitution Method | Restore with 1.2% sodium acetate or neutral PBS |
Concentration | 0,1 mg/ml (after reconstitution with PBS) |
Purification | Affinity chromatography |
Conjugation | Unconjugated |
Storage Condition | Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | B-cell CLL/lymphoma 2 |
Database Link | |
Background | Immunoreactive BCL2 protein in the neoplastic cells of almost all follicular lymphomas whereas no BCL2 protein was detected in follicles affected by nonneoplastic processes or in normal lymphoid tissue. Every tumor with molecular-genetic evidence of t(14;18) translocation expressed detectable levels of BCL2 protein, regardless of whether the breakpoint was located in or at a distance from the BCL2 gene. Overexpression of BCL2 blocks the apoptotic death of a pro-B-lymphocyte cell line. |
Synonyms | BCL2, Bcl-2 alpha |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane |
Protein Pathways | Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Focal adhesion, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
---|
Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura.
,null,
Journal of nephrology
,PubMed ID 29497996
[BCL2]
|
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...