TPM1 (Sarcomeric) Mouse Monoclonal Antibody [Clone ID: ST-39]

Specifications

Product Data
Clone Name	ST-39
Applications	IF, IHC, IP, WB
Recommend Dilution	Western Blot: 1 - 2 μg/ml. Immunohistochemistry on frozen and paraffin sections: 2 - 4 μg/ml.
Reactivity	Chicken, Human, Rabbit, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Chicken muscle tropomyosin
Specificity	This antibody reacts to Tropomyosin-1.
Formulation	1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative State: Purified State: Lyphilized purified Ig fraction
Reconstitution Method	Restore with 1.2% sodium acetate or neutral PBS.
Concentration	0,1 mg/ml (after reconstitution with PBS)
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tropomyosin 1 (alpha)
Database Link	Entrez Gene 24851 RatEntrez Gene 7168 Human UniProt ID P09493
Background	The tropomyosins are a family of actin filament binding proteins. These proteins were first isolated from skeletal muscle, but later identified in many nonmuscle tissues. Tropomyosins are ubiquitous proteins of 35 to 45 kD associated with the actin filaments of myofibrils and stress fibers. Vertebrates have at least 4 different tropomyosin genes; in humans, they are named TPM1, TPM2, TPM3, and TPM4. Tropomyosins expressed as different isoforms in muscle and non-muscle cells.
Synonyms	Tropomyosin alpha-1 chain, Alpha-tropomyosin, TMSA, C15orf13
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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