ICAM3 Mouse Monoclonal Antibody [Clone ID: MEM-04]
CAT#: AM26001LE-N
ICAM3 mouse monoclonal antibody, clone MEM-04, Low Endotoxin
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CNY 3,140.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | MEM-04 |
Applications | FC, FN, IHC |
Recommend Dilution | Flow cytometry: 5 µg/ml. Immunohistochemistry on paraffin sections: 10 µg/ml. Positive control: tonsil. Functional application: blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1). |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Leukocytes of a patient suffering from LGL-type leukemia |
Specificity | The antibody MEM-04 reacts with CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes. |
Formulation | Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. State: Low Endotoxin State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Gene Name | intercellular adhesion molecule 3 |
Database Link | |
Background | CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes. |
Synonyms | ICAM-3, ICAM-R, CDw50 |
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